About: Mesna

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Mesna
rdfs:subClassOf	Uroprotective Agent
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Mesna
NSC_Code	113891
UMLS_CUI	C0000294
CAS_Registry	19767-45-4
Accepted_Therapeutic_Use_For	Ifosfamide-induced hemorrhagic cystitis, prophylaxis
In_Clinical_Trial_For	Advanced cancer; Breast cancer; Leukemia
FDA_UNII_Code	NR7O1405Q9
Contributing_Source	FDA
ALT_DEFINITION	A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39759
PDQ_Closed_Trial_Search_ID	39759
Chemical_Formula	C2H5O3S2.Na
Legacy_Concept_Name	Mesna
FULL_SYN	MistabroncoSYDTPNSC0113891 MistabroncoFBNCI 2-Mercaptoethanesulfonate, Sodium SaltPTDCP01550 Sodium 2-Mercaptoethane SulfonateSNNCI Sodium 2-MercaptoethanesulphonateSNNCI MESNAPTFDANR7O1405Q9 MercaptoethanesulfonateSYNCI MesnaSYDTPNSC0113891 Mercaptoethane SulfonateSYNCI mesnaPTNCI-GLOSSCDR0000045257 MexanFBNCI MesnaPTNCI ZikenFBNCI D-7093CNNCI MesnilFBNCI MesnexBRNCI MesnumSYNCI FilesnaFBNCI MitexanFBNCI MucofluidSYDTPNSC0113891 UCB 3983CNNCI MucoleneFBNCI UromitexanSYDTPNSC0113891 2-Mercaptoethanesulfonic Acid Sodium SaltSNNCI MucofluidFBNCI AusobroncFBNCI MistabronFBNCI UromitexanFBNCI
DEFINITION	A sulfhydryl compound that is used to reduce the incidence of hemorrhagic cystitis associated with certain chemotherapeutic agents. Mesna is converted to a free thiol compound in the kidney, where it binds to and inactivates acrolein and other urotoxic metabolites of ifosfamide and cyclophosphamide, thereby reducing their toxic effects on the urinary tract during urinary excretion. (NCI04)NCI
code	C192
is someValuesFrom of	nodeID://b642230 nodeID://b652292 nodeID://b654509 nodeID://b657122 nodeID://b657195 nodeID://b657604 nodeID://b660402 nodeID://b665912 nodeID://b665943 nodeID://b671123 nodeID://b671124 nodeID://b671129 nodeID://b682155 nodeID://b688107 nodeID://b689790 nodeID://b705942 nodeID://b717771 nodeID://b722569 nodeID://b722884

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