About: VAV1 Protein     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • VAV1 Protein
rdfs:subClassOf
OMIM_Number
  • 164875
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • VAV1 Protein
UMLS_CUI
  • C1451772
Legacy_Concept_Name
  • VAV1_Protein
FULL_SYN
  • VAV1 ProteinPTNCI
  • VAVSYNCI
  • VAV1SYNCI
  • VAV1 Gene ProductSYNCI
Swiss_Prot
  • P15498
DEFINITION
  • VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and two zinc finger-like domains. VAV also has an SH2, two SH3, and a guanosine exchange factor domain. Truncation of its N-terminus, containing an HLH domain and leucine zipper, activates its oncogenic potential. Wild type VAV is transcribed in hematopoietic cells, including erythroid, lymphoid, and myeloid lineages. VAV-dependent signaling pathways regulate the maturation of T-cells. (from OMIM 164875 and NCI)NCI
code
  • C18283
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