About: Tissue Inhibitor of Metalloproteinases     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tissue Inhibitor of Metalloproteinases
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
Preferred_Name
  • Tissue Inhibitor of Metalloproteinases
UMLS_CUI
  • C0145988
ALT_DEFINITION
  • 21-27 kDa proteins found in the extracellular matrix; regulate the activity of collagenase and therefore are important in tumorigenesis, angiogenesis, chondrosteosis, and other tissue forming processes.CSP2000
Legacy_Concept_Name
  • Tissue_Inhibitor_of_Metalloproteinases
FULL_SYN
  • TIMPSYNCI
  • Tissue Inhibitor of MetalloproteinasesPTNCI
DEFINITION
  • Tissue inhibitors of metalloproteinase. A family of proteins of around 200 residues that can inhibit enzymes of the metalloprotease type, for example collagenase, by binding to them. (DCB-CB)NCI
DesignNote
  • TIMP family members may possess selective affinities for matrix metalloproteinases. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions.
code
  • C17544
is rdf:first of
is someValuesFrom of
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