About: Recombinant Interleukin-14     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Interleukin-14
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Interleukin-14
UMLS_CUI
  • C1522568
Legacy_Concept_Name
  • Therapeutic_Interleukin-14
FULL_SYN
  • Interleukin 14SYNCI
  • High Molecular Weight-B-Cell Growth FactorSYNCI
  • Recombinant Interleukin-14PTNCI
  • IL-14ABNCI
  • HMW-BCGFABNCI
DEFINITION
  • A recombinant peptide, which is chemically identical or similar to the endogenous cytokine interleukin-14 (IL-14). The cytokine inhibits immunoglobulin secretion and selectively expands activated B-cell subpopulations. An IL-14 receptor is found on activated B-cells, but not in resting B-cells. This agent is unrelated to other cytokines but has homology with complement factor Bb. Autocrine or paracrine production of IL-14 may play a significant role in the rapid proliferation of aggressive non-Hodgkin's lymphoma (NHL-B). Interrupting this pathway could be a useful goal of therapy for patients resistant to conventional chemotherapy.NCI
code
  • C1630
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