About: Piperacillin-Tazobactam     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Piperacillin-Tazobactam
rdfs:subClassOf
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Piperacillin-Tazobactam
UMLS_CUI
  • C0250480
ALT_DEFINITION
  • A drug combination that is used to treat infection in people with cancer. Piperacillin is a synthetic penicillin; tazobactam enhances the effectiveness of piperacillin.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43437
PDQ_Closed_Trial_Search_ID
  • 43437
Legacy_Concept_Name
  • Piperacillin-Tazobactam
FULL_SYN
  • piperacillin-tazobactamPTNCI-GLOSSCDR0000046674
  • Piperacillin-TazobactamPTNCI
  • Piperacillin/TazobactamSYNCI
  • ZosynBRNCI
  • PIPER/TAZOSYNCI
DEFINITION
  • A combination formulation of the antibiotic piperacillin and the beta-lactamase inhibitor tazobactam with antibacterial activity. Piperacillin, a broad-spectrum, semisynthetic penicillin, binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall, thereby interfering with the cross-linking of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. As a result, the cell wall is weakened and the cell lyses. Tazobactam, a penicillanic acid sulfone derivative, irreversibly binds to and inhibits bacterial beta-lactamase at or near its active site, thereby preventing the destruction of the beta-lactamase susceptible piperacillin by this bacterial enzyme.NCI
code
  • C1530
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