About: PH Domain

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Attributes	Values
rdf:type	Class
rdfs:label	PH Domain
rdfs:subClassOf	Protein Domain
Semantic_Type	Amino Acid Sequence
Preferred_Name	PH Domain
UMLS_CUI	C1518792
Legacy_Concept_Name	PH_Domain
FULL_SYN	Pleckstrin Homology DomainSYNCI Pleckstrin-Homology DomainSYNCI PH DomainPTNCI
DEFINITION	Pleckstrin-homology (PH) domains are protein modules of approximately 120 amino acids found in a wide variety of signaling proteins in organisms ranging from yeast to humans. Some PH domains bind with high affinity (low mM or nM Kd) to specific phosphoinositides such as phosphatidyl-inositol (PI) -4,5-bisphosphate, PI-3,4-P2 or PI-3,4,5-P3. Binding to phosphoinositides may allow PH proteins to respond to lipid messengers for example by relocation to membranes. The C-termini of some PH domains have also been reported to bind the beta/lambda subunits of heterotrimeric G proteins.NCIPawson Lab, SLRI, Mount Sinai Hospital, 2003
code	C14077
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