About: ETS Domain

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Attributes	Values
rdf:type	Class
rdfs:label	ETS Domain
rdfs:subClassOf	DNA Binding Domain
Semantic_Type	Amino Acid Sequence
Preferred_Name	ETS Domain
UMLS_CUI	C1512142
Legacy_Concept_Name	ETS_Domain
FULL_SYN	ETS DomainPTNCI
DEFINITION	Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich DNA with a GGAA/T core. Identified in many transcription factors, many ETS-proteins modulate gene expression through protein-protein interactions with other transcriptional factors and co-factors. Most ETS-proteins are nuclear targets of RAS-MAPK signaling; some affect cell proliferation or apoptosis-related genes. Several are expressed in specific cell lineages to regulate development and differentiation. Deregulated ETS-gene expression or chimeric ETS-proteins are associated with leukemias, some tumors, invasion and metastasis. (NCI)NCI
code	C13719
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