About: Itraconazole     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Itraconazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
Preferred_Name
  • Itraconazole
UMLS_CUI
  • C0064113
CAS_Registry
  • 84625-61-6
Accepted_Therapeutic_Use_For
  • Fungal Infections
In_Clinical_Trial_For
  • Acute myeloid leukemia; chemotherapy-induced fungal infection; myelodysplasic syndrome
FDA_UNII_Code
  • 304NUG5GF4
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to prevent or treat fungal infections. It belongs to the family of drugs called antifungal agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39106
PDQ_Closed_Trial_Search_ID
  • 39106
Chemical_Formula
  • C35H38Cl2N8O4
Legacy_Concept_Name
  • Itraconazole
CHEBI_ID
  • CHEBI:6076
FULL_SYN
  • ITRACONAZOLEPTFDA304NUG5GF4
  • OriconazoleSYNCI
  • ItraconazolePTNCI
  • itraconazolePTNCI-GLOSSCDR0000045161
  • (+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-oneSNNCI
  • R 51,211CNNCI
  • SporanoxBRNCI
DEFINITION
  • A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fugal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04)NCI
code
  • C1138
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