About: Staphylococcal Enterotoxin A     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Staphylococcal Enterotoxin A
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Staphylococcal Enterotoxin A
UMLS_CUI
  • C0059385
CAS_Registry
  • 37337-57-8
PDQ_Open_Trial_Search_ID
  • 42927
PDQ_Closed_Trial_Search_ID
  • 42927
Legacy_Concept_Name
  • Staphylococcal_Enterotoxin_A
FULL_SYN
  • SEAABNCI
  • Staphylococcal Enterotoxin APTNCI
DEFINITION
  • A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin A (SEA), a gram positive bacterial superantigen (SAg), is a potent stimulator of T-cell activation. SEA superantigen binds directly to class II major histocompatibility complex (MHC) molecules and to the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEA, both CD4+ and CD8+ cells proliferate, secrete cytokines, and demonstrate enhanced cytotoxic activity against a broad range of antigens. Vaccination with the SEA protein, administered by direct transfection into tumor cells, may elicit a non-specific cytotoxic T-cell (CTL) response and result in decreased tumor cell growth.NCI
code
  • C1083
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