About: Fluorine F 18 4-L-fluoroglutamine (2S,4R)     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Fluorine F 18 4-L-fluoroglutamine (2S,4R)
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Fluorine F 18 4-L-fluoroglutamine (2S,4R)
NCI_META_CUI
  • CL437435
PDQ_Open_Trial_Search_ID
  • 741122
PDQ_Closed_Trial_Search_ID
  • 741122
FULL_SYN
  • 18F FluoroglutamineSYNCI
  • Fluorine F 18 4-L-fluoroglutamine (2S,4R)PTNCI
  • [18F] 4-L-fluoroglutamine (2S,4R)SYNCI
DEFINITION
  • A radioconjugate and glutamine analog consisting of the fluorine F 18 labeled 2S, 4R stereoisomer of 4-fluoroglutamine with potential use as a metabolic tracer for tumor imaging. Upon intravenous administration, fluorine F 18 4-L-fluoroglutamine (2S,4R) is preferentially taken up by cancer cells, possibly driven by c-Myc upregulation. Upon positron emission tomography (PET), cancer cells can be imaged. Tumor cells use the amino acid glutamine for nutritional purposes necessary for energy production and growth; as tumor cells proliferate more rapidly than normal healthy cells, glutamine uptake is higher in certain cancer cells.NCI
code
  • C103196
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