About: Pan-Selectin Antagonist GMI-1070     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Pan-Selectin Antagonist GMI-1070
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pan-Selectin Antagonist GMI-1070
UMLS_CUI
  • C2973594
PDQ_Open_Trial_Search_ID
  • 736621
PDQ_Closed_Trial_Search_ID
  • 736621
FULL_SYN
  • GMI-1070CNNCI
  • Pan-Selectin Antagonist GMI-1070PTNCI
DEFINITION
  • A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, GMI-1070 prevents the interaction between leukocytes and the endothelium and may prevent cell activation and adhesion. By preventing selectin-mediated cell adhesion in sickle cell anemia, this agent may inhibit red blood cell-white blood cell interactions, normalize blood flow and reduce inflammation and vascular occlusive pain. GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins. Selectins, containing lectin- and EGF-like domains, are a family of cell adhesion molecules implicated in inflammatory processes and cancer.NCI
code
  • C102786
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