About: Glucarpidase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Glucarpidase is the recombinant form of the Pseudomonas sp. (strain RS-16) enzyme carboxypeptidase G2 that is produced in Escherichia coli. In patients, glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. Therefore since methotrexate is eliminated enzymatically and not by the kidneys, glucarpidase is indicated in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (>1 micromole per liter). Glucarpidase is marketed under the brand name Voraxaze®. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5B79-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Green JM: Glucarpidase to combat toxic levels of methotrexate in patients. Ther Clin Risk Manag. 2012;8:403-13. doi: 10.2147/TCRM.S30135. Epub 2012 Nov 22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23209370 # Tuffaha HW, Al Omar S: Glucarpidase for the treatment of life-threatening methotrexate overdose. Drugs Today (Barc). 2012 Nov;48(11):705-11. doi: 10.1358/dot.2012.48.11.1871575. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/23170306 # FDA label. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	In healthy patients not taking methotrexate, glucarpidase has an elimination half-life of 5.6 hours. In patients with severe renal impairment (creatinine clearance <30 mL/min), glucarpidase has an longer elimination half-life at 8.2 hours. (en)
http://linked.open...ugbank/indication	Used in patients on methotrexate treatment who have kidney dysfunction, and are experiencing an abnormally high plasma concentration of methotrexate (> 1 micromole per liter). (en)
sameAs	Glucarpidase
Title	Glucarpidase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB08898/identifier/drugbank/DB08898 http://linked.opendata.cz/resource/drugbank/drug/DB08898/identifier/kegg-drug/D10260 http://linked.opendata.cz/resource/drugbank/drug/DB08898/identifier/national-drug-code-directory/50633-210-11 http://linked.opendata.cz/resource/drugbank/drug/DB08898/identifier/uniprotkb/P06621 http://linked.opendata.cz/resource/drugbank/drug/DB08898/identifier/wikipedia/Glucarpidase
http://linked.open...mechanismOfAction	Glucarpidase inactivates methotrexate, and other antifolates, by hydrolyzing glutamate on the carboxyl terminal of these compounds. For methotrexate specifically, it is hydrolyzed to the inactive metabolites glutamate and 4-deoxy-4-amino-N10-methylpteroic acid (DAMPA). (en)
http://linked.open...outeOfElimination	Route of elmination was not determined. (en)
http://linked.open.../drugbank/synonym	Carboxypeptidase G2 (en) Folate hydrolase G2 (en) Glutamate carboxypeptidase (en) Pteroylmonoglutamic acid hydrolase G2 (en)
http://linked.open...drugbank/toxicity	Most common adverse reactions include hypotension, flushing, nausea, vomiting, headache, and paresthesia. (en)
http://linked.open...umeOfDistribution	Glucarpidase is likely limited to the plasma volume since its volume of distribution is 3.6 L. (en)
http://linked.open...k/foodInteraction	No food effects were found. (en)
http://linked.open...nk/proteinBinding	Plasma protein binding was not quantified. (en)
foaf:page	http://www.drugs.com/mtm/glucarpidase.html http://www.rxlist.com/voraxaze-drug.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5B7B-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5B7A-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Glucarpidase
http://linked.open...ugbank/absorption	In healthy patients not taking methotrexate, the average maximum concentration for glucarpidase was 3.3 μg/mL. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9074-87-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	In healthy patients not taking methotrexate, glucarpidase has a clearance of 7.5 mL/min. (en)

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