About: recombinant human relaxin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Recombinant human relaxin is a hormone produced during pregnancy that facilitates the birth process by causing a softening and lengthening of the cervix and the pubic symphysis (the place where the pubic bones come together).It is a heterodimer protein secreted by the corpus luteum and placenta during pregnancy. (en)
http://linked.open...generalReferences	# Debrah DO, Novak J, Matthews JE, Ramirez RJ, Shroff SG, Conrad KP: Relaxin is essential for systemic vasodilation and increased global arterial compliance during early pregnancy in conscious rats. Endocrinology. 2006 Nov;147(11):5126-31. Epub 2006 Jul 27. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16873529 # Nistri S, Cinci L, Perna AM, Masini E, Mastroianni R, Bani D: Relaxin induces mast cell inhibition and reduces ventricular arrhythmias in a swine model of acute myocardial infarction. Pharmacol Res. 2007 Nov 9;. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18068999 (en)
http://linked.open...gy/drugbank/group	investigational (en)
http://linked.open...ugbank/indication	Investigated for use/treatment in cardiovascular disorders, congestive heart failure, infertility, peripheral vascular disease, and scleroderma. (en)
sameAs	recombinant human relaxin
Title	recombinant human relaxin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB05794/identifier/drugbank/DB05794 http://linked.opendata.cz/resource/drugbank/drug/DB05794/identifier/pubchem-compound/19261 http://linked.opendata.cz/resource/drugbank/drug/DB05794/identifier/wikipedia/Relaxin
http://linked.open...mechanismOfAction	Recombinant human relaxin inhibits contractions of the uterus and may play a role in timing of delivery. Relaxin works by simultaneously cutting collagen production and increasing collagen breakdown. (en)
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B46BC-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B46BB-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)

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