About: LJP 1082     Goto   Sponge   Distinct   Permalink

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http://linked.open...gbank/description
  • LJP 1082 is a Toleragen that is designed to shut down the B cells that produce antibodies to ß2 GP1. LJP 1082 is undergoing trial for for the treatment of stroke, deep-vein thrombosis and other conditions associated with antibody-mediated thrombosis. Antibody-mediated thrombosis, also called antiphospholipid syndrome (APS), is a blood clotting disorder. Patients with high levels of anticardiolipin antibodies (ACA) have an increased risk of stroke, heart attack, deep vein thrombosis, and recurrent fetal loss. The target of the LJP 1082's clot-promoting antibodies is a small region on a key blood protein called beta 2-glycoprotein I. To date, our scientists have shown that approximately 90% of patients studied with antibody-mediated thrombosis have antibodies that bind to this region. (en)
http://linked.open...generalReferences
  • # Cockerill KA, Iverson GM, Jones DS, Linnik MD: Therapeutic potential of toleragens in the management of antiphospholipid syndrome. BioDrugs. 2004;18(5):297-305. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15377172 # Merrill JT: LJP 1082: a toleragen for Hughes syndrome. Lupus. 2004;13(5):335-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15230288 # Bayes M, Rabasseda X, Prous JR: Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Dec;25(10):831-55. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14735233 (en)
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  • investigational (en)
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  • Investigated for use/treatment in autoimmune diseases, strokes, and thrombosis. (en)
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Title
  • LJP 1082 (en)
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http://linked.open...mechanismOfAction
  • The target of the LJP 1082's clot-promoting antibodies is a small region on a key blood protein called beta 2-glycoprotein I. (en)
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