About: Phenoxodiol     Goto   Sponge   Distinct   Permalink

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http://linked.open...gbank/description
  • Phenoxodiol is a substance that is being studied in the treatment of cancer. It belongs to the family of drugs called signal transduction inhibitors. (en)
http://linked.open...generalReferences
  • # Herst PM, Petersen T, Jerram P, Baty J, Berridge MV: The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Biochem Pharmacol. 2007 Dec 3;74(11):1587-95. Epub 2007 Aug 19. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17904534 # Choueiri TK, Wesolowski R, Mekhail TM: Phenoxodiol: isoflavone analog with antineoplastic activity. Curr Oncol Rep. 2006 Mar;8(2):104-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16507219 # Mor G, Fu HH, Alvero AB: Phenoxodiol, a novel approach for the treatment of ovarian cancer. Curr Opin Investig Drugs. 2006 Jun;7(6):542-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16784025 # Klein R, Brown D, Turnley AM: Phenoxodiol protects against Cisplatin induced neurite toxicity in a PC-12 cell model. BMC Neurosci. 2007 Aug 1;8:61. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17672914 (en)
http://linked.open...gy/drugbank/group
  • investigational (en)
http://linked.open...ugbank/indication
  • Intended for the treatment of various forms of cancer. (en)
sameAs
Title
  • Phenoxodiol (en)
adms:identifier
http://linked.open...mechanismOfAction
  • The antiproliferative effects of phenoxodiol are associated with inhibition of plasma membrane electron transport in tumour cell lines and primary immune cells. Results from one study (PMID: 17904534) indicate that plasma membrane electron transport (PMET) may be a primary target for phenoxodiol in tumour cells and in activated T cells. (en)
http://linked.open.../drugbank/synonym
  • 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol (en)
  • Dehydroequol (en)
  • Haginin E (en)
  • Idronoxil (en)
  • NV-06 (en)
  • NV06 (en)
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  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 81267-65-4 (en)
http://linked.open...drugbank/category
  • (en)
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