About: Homoharringtonine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Homoharringtonine, AKA HHT or omacetaxine mepesuccinate, is a cephalotaxine ester and protein synthesis inhibitor with established clinical activity as a single agent in hematological malignancies. Homoharringtonine is synthesized from cephalotaxine, which is an extract from the leaves of the plant, Cephalotaxus species. In October 2005, homoharringtonine received Orphan Drug designation from the EMEA for the treatment of chronic myeloid leukemia (CML). Then in March 2006, homoharringtonine received Orphan Drug status from the FDA for the treatment of CML. In November 2006, homoharringtonine, for the treatment of CML, was granted Fast Track designation by the FDA. Most recently, in October 2012, homoharringtonine was marketed under the brand name Synribo™ and FDA approved for patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5B05-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Lou YJ, Qian WB, Jin J: Homoharringtonine induces apoptosis and growth arrest in human myeloma cells. Leuk Lymphoma. 2007 Jul;48(7):1400-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17613769 # Jie H, Donghua H, Xingkui X, Liang G, Wenjun W, Xiaoyan H, Zhen C: Homoharringtonine-induced apoptosis of MDS cell line MUTZ-1 cells is mediated by the endoplasmic reticulum stress pathway. Leuk Lymphoma. 2007 May;48(5):964-77. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17487741 # FDA label. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Homoharringtonine has a half life of about 6 hours after subcutaneous administration. (en)
http://linked.open...ugbank/indication	Used in patients who are intolerant and/or resistant to two or more tyrosine kinase inhibitors used to treat accelerated or chronic phase CML. (en)
sameAs	Homoharringtonine
Title	Homoharringtonine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/chebi/71019 http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/chemspider/65276 http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/drugbank/DB04865 http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/kegg-drug/D08956 http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/national-drug-code-directory/63459-177-14 http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/pubchem-compound/72332 http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/pubchem-substance/11075063 http://linked.opendata.cz/resource/drugbank/drug/DB04865/identifier/wikipedia/Omacetaxine_mepesuccinate
http://linked.open...mechanismOfAction	Homoharringtonine inhibits protein synthesis by not directly binding to Bcr-Abl. It binds to the A-site cleft in the large ribosomal subunit, which affects chain elongation and prevents protein synthesis. (en)
http://linked.open...outeOfElimination	The main route of elimination for homoharringtonine is still unknown, but renal elimination is less than 15%. (en)
http://linked.open.../drugbank/synonym	CGX-635 (en) Cephalotaxus alkaloid (en) HHT (en) Myelostat (en) omacetaxine mepesuccinate (en)
http://linked.open...drugbank/toxicity	The most severe adverse effects after homoharringtonine administration are myelosuppression, bleeding, hyperglycemia, and fetal harm. (en)
http://linked.open...umeOfDistribution	Homoharringtonine has a steady state Vd of 141 ± 93.4 L. (en)
http://linked.open...k/foodInteraction	Homoharringtonine is administered subcutaneously, so food should have no effects. (en)
http://linked.open...nk/proteinBinding	Plasma protein binding is equal or less than 50%. (en)
http://linked.open...ynthesisReference	Yaguang Liu, "Process for producing harringtonine and homoharringtonine." U.S. Patent US4783454, issued June, 1980. (en)
foaf:page	http://www.drugs.com/cdi/omacetaxine-injection.html http://www.rxlist.com/synribo-drug.htm
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http://linked.open...l/drug/hasATCCode	Omacetaxine mepesuccinate
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http://linked.open...ugbank/absorption	Homoharringtonine absorption was not quantified, but maximum concentration is reached after about 30 mins. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	26833-87-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	Clearance for homoharringtonine was not quantified. (en)
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