About: Flunitrazepam

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A benzodiazepine with pharmacologic actions similar to those of diazepam that can cause anterograde amnesia. Some reports indicate that it is used as a date rape drug and suggest that it may precipitate violent behavior. The United States Government has banned the importation of this drug. [PubChem] (en)
http://linked.open...generalReferences	# Rickels K: The clinical use of hypnotics: indications for use and the need for a variety of hypnotics. Acta Psychiatr Scand Suppl. 1986;332:132-41. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2883820 # Robertson MD, Drummer OH: Postmortem drug metabolism by bacteria. J Forensic Sci. 1995 May;40(3):382-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7782744 # Oelschlager H: [Chemical and pharmacologic aspects of benzodiazepines] Schweiz Rundsch Med Prax. 1989 Jul 4;78(27-28):766-72. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2570451 # Usami N, Yamamoto T, Shintani S, Ishikura S, Higaki Y, Katagiri Y, Hara A: Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11995921 # Tokunaga S, Takeda Y, Shinomiya K, Hirase M, Kamei C: Effects of some H1-antagonists on the sleep-wake cycle in sleep-disturbed rats. J Pharmacol Sci. 2007 Feb;103(2):201-6. Epub 2007 Feb 8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17287588 (en)
http://linked.open...gy/drugbank/group	approved (en) illicit (en)
http://linked.open...drugbank/halfLife	18-26 hours (en)
http://linked.open...ugbank/indication	For short-term treatment of severe insomnias, that are not responsive to other hypnotics. (en)
sameAs	Flunitrazepam
Title	Flunitrazepam (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/bindingdb/25878 http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/chemspider/3263 http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/drugbank/DB01544 http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/kegg-drug/D01230 http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/pubchem-compound/3380 http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/pubchem-substance/46504553 http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/pharmgkb/PA164781320 http://linked.opendata.cz/resource/drugbank/drug/DB01544/identifier/wikipedia/Flunitrazepam
http://linked.open...mechanismOfAction	Benzodiazepines bind nonspecifically to benzodiazepine receptors BNZ1, which mediates sleep, and BNZ2, which affects affects muscle relaxation, anticonvulsant activity, motor coordination, and memory. As benzodiazepine receptors are thought to be coupled to gamma-aminobutyric acid-A (GABAA) receptors, this enhances the effects of GABA by increasing GABA affinity for the GABA receptor. Binding of the inhibitory neurotransmitter GABA to the site opens the chloride channel, resulting in a hyperpolarized cell membrane that prevents further excitation of the cell. (en)
http://linked.open.../drugbank/synonym	Rohypnol (en) Flunitrazepamum (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include confusion, coma, impaired coordination, sleepiness, and slowed reaction time. (en)
http://linked.open...k/foodInteraction	Avoid alcohol. (en) Avoid taking with grapefruit juice. (en) Take with food. (en) Avoid excessive quantities of coffee or tea (Caffeine). (en)
http://linked.open...ynthesisReference	Kariss, J. and Newmark, H.L.; U.S. Patent 3,116,203; December 31, 1963; assigned to Hoffmann-la Roche Inc.  Kariss, J. and Newmark, H.L.; US. Patent 3,123,529; March 3,1964; assigned to Hoffmann-La Roche Inc.  Keiler, O., Steiger, N. and Sternbach, L.H.; U.S. Patent 3,203,990; August 31, 1965; assigned to Hoffmann-La Roche Inc. (en)
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http://linked.open...ugbank/absorption	50% (suppository) and 64-77% (oral) (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	1622-62-4 (en)
http://linked.open...drugbank/category	(en)
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