About: Ergonovine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An ergot alkaloid with uterine and vascular smooth muscle contractile properties. [PubChem] (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	t<sub>1/2 α</sub>=10 minutes; t<sub>1/2 β</sub>=2 hours (en)
http://linked.open...ugbank/indication	Used to treat postpartum haemorrhage and postabortion haemorrhage in patients with uterine atony. (en)
sameAs	Ergonovine
Title	Ergonovine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/chebi/4822 http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/chemspider/391970 http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/drugbank/DB01253 http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/kegg-compound/C07543 http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/pharmgkb/PA449487 http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/pubchem-compound/443884 http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/pubchem-substance/46506922 http://linked.opendata.cz/resource/drugbank/drug/DB01253/identifier/wikipedia/Ergonovine
http://linked.open...mechanismOfAction	Ergonovine directly stimulates the uterine muscle to increase force and frequency of contractions. With usual doses, these contractions precede periods of relaxation; with larger doses, basal uterine tone is elevated and these relaxation periods will be decreased. Contraction of the uterine wall around bleeding vessels at the placental site produces hemostasis. Ergonovine also induces cervical contractions. The sensitivity of the uterus to the oxytocic effect is much greater toward the end of pregnancy. The oxytocic actions of ergonovine are greater than its vascular effects. Ergonovine, like other ergot alkaloids, produces arterial vasoconstriction by stimulation of alpha-adrenergic and serotonin receptors and inhibition of endothelial-derived relaxation factor release. It is a less potent vasoconstrictor than ergotamine. As a diagnostic aid (coronary vasospasm), ergonovine causes vasoconstriction of coronary arteries. (en)
http://linked.open...drugbank/packager	A-S Medication Solutions LLC Baxter International Inc. Ben Venue Laboratories Inc. Sandoz Cardinal Health Carlisle Laboratories Inc. Central Texas Community Health Centers Claris Lifesciences Inc. Community Action Inc. Community Health Services Actavis Group Allergan Inc. A-S Medication Solutions LLC CVS Pharmacy
http://linked.open...outeOfElimination	Thought to be eliminated by non-renal mechanisms (i.e. hepatic metabolism, excretion in feces) (en)
http://linked.open.../drugbank/synonym	Ergometrine (en) Ergonovine (en) Ergobasine (en) Ergotrate maleate (en) (6AR,9R)-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide (en) D-Lysergic acid 1-hydroxymethylethylamide (en) D-Lysergic acid-L-propanolamide (en) Ergometrina (en) Ergometrinum (en) 9,10-Didehydro-N-(alpha-(hydroxymethyl)ethyl)-6-methylergoline-8-beta-carboxamide (en) N-(2-Hydroxy-1-methylethyl)-D(+)-lysergamide (en) N-(alpha-(Hydroxymethyl)ethyl)-D-lysergamide (en) 9,10-Didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8beta(S)-carboxamide (en) [8beta(S)]-9,10-Didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide (en)
http://linked.open...drugbank/toxicity	The principal symptoms of overdose are convulsions and gangrene. Other symptoms include bradycardia, confusion, diarrhoea, dizziness, dyspnoea, drowsiness, fast and/or weak pulse, miosis, hypercoagulability, loss of consciousness, nausea and vomiting, numbness and coldness of the extremities, pain in the chest, peripheral vasoconstriction, respiratory depression, rise or fall in blood pressure, severe cramping of the uterus, tachycardia, tingling, and unusual thirst. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/76-00-00
foaf:page	http://www.drugs.com/cdi/ergonovine.html
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5F76-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B5F7C-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5F7B-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5F78-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5F79-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5F7A-363D-11E5-9242-09173F13E4C5
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http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B5F73-363D-11E5-9242-09173F13E4C5
http://linked.open...logy/drugbank/pKa	http://linked.opendata.cz/resource/drugbank/property/271B5F8F-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Ergometrine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5F82-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5F83-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5F7D-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B5F7E-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B5F80-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5F7F-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5F81-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Absorption is rapid and complete after oral or intramuscular administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	60-79-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Ergonovine maleate 100% powder
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B5F88-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B5F8A-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B5F8B-363D-11E5-9242-09173F13E4C5
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http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B5F87-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B5F86-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B5F89-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5F77-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B5F84-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5F85-363D-11E5-9242-09173F13E4C5

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