| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem] (en)
|
| http://linked.open...y/drugbank/dosage
| |
| http://linked.open...gy/drugbank/group
| - approved (en)
- withdrawn (en)
|
| http://linked.open...drugbank/halfLife
| |
| http://linked.open...ugbank/indication
| - For the treatment of the following infections (skin, UTI, ENT) caused by; <i>S. pneumoniae, H. influenzae, staphylococci, S. pyogenes</i> (group A beta-hemolytic streptococci), <i>E. coli, P. mirabilis, Klebsiella</i> sp, coagulase-negative staphylococci and <i>Streptococcus pyogenes</i> (en)
|
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - Over 90% of the drug is excreted unchanged in the urine within 24 hours. It crosses the placenta and appears in breast milk. (en)
|
| http://linked.open.../drugbank/synonym
| - Cefadroxil (en)
- CDX (en)
- Cefadroxil anhydrous (en)
- Cefadroxil monohydrate (en)
- Cefadroxilo (en)
- Cefadroxilum (en)
- Cephadroxil (en)
- D-Cefadroxil (en)
- (6R,7R)-7-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (en)
|
| http://linked.open...drugbank/toxicity
| - Nausea, vomiting, diarrhoea, allergic rashes may occur (en)
|
| http://linked.open.../drug/hasAHFSCode
| |
| http://linked.open...k/foodInteraction
| - Food may reduce the digestive problems that sometimes occur. (en)
- Take without regard to meals. (en)
|
| http://linked.open...nk/proteinBinding
| - Binding rates of cefadroxil were 28.1% by U.F. method (en)
|
| http://linked.open...ynthesisReference
| - Leonardo Marsili, "Substantially anhydrous crystalline cefadroxil and method for producing it." U.S. Patent US5329001, issued April, 1978. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption. (en)
|
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