About: Emedastine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Emedastine is an antihistamine used in eye drops to treat allergic conjunctivitis. [Wikipedia] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B62C6-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The elimination half-life of oral emedastine in plasma is 3-4 hours. (en)
http://linked.open...ugbank/indication	For the temporary relief of the signs and symptoms of allergic conjunctivitis. (en)
sameAs	Emedastine
Title	Emedastine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/bindingdb/50019624 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/chebi/4779 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/chemspider/3106 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/drugbank/DB01084 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/kegg-compound/C07785 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/national-drug-code-directory/0065-0325-05 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/pubchem-compound/3219 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/pubchem-substance/46505109 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/pharmgkb/PA164751802 http://linked.opendata.cz/resource/drugbank/drug/DB01084/identifier/wikipedia/Emedastine
http://linked.open...mechanismOfAction	Emedastine is a relatively selective, histamine H<sub>1</sub> antagonist. In vitro examinations of emedastine's affinity for histamine receptors demonstrate relative selectivity for the H<sub>1</sub> histamine receptor. In vivo studies have shown concentration-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva following topical ocular administration. Emedastine appears to be devoid of effects on adrenergic, dopaminergic and serotonin receptors. (en)
http://linked.open...drugbank/packager	Alcon Laboratories
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5441958
http://linked.open...outeOfElimination	Approximately 44% of the oral dose is recovered in the urine over 24 hours with only 3.6% of the dose excreted as parent drug. Two primary metabolites, 5- and 6-hydroxyemedastine, are excreted in the urine as both free and conjugated forms. (en)
http://linked.open.../drugbank/synonym	EMEDASTINE (en) Emedastine difumarate (en) 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)benzimidazole (en) 1-(2-Ethoxy-ethyl)-2-(4-methyl-[1,4]diazepan-1-yl)-1H-benzoimidazole (en) Emedastina (en) Emedastinum (en) 1-[2-(Ethoxy)ethyl]-2-(4-methyl-1-homopiperazinyl)benzimidazole (en)
http://linked.open...drugbank/toxicity	Somnolence and malaise have been reported following daily oral administration. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/52-02-00
foaf:page	http://www.drugs.com/mtm/emedastine-ophthalmic.html http://www.rxlist.com/cgi/generic2/emedastine.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B62CB-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B62D1-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B62D0-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B62CD-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B62CE-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B62CF-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B62C9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B62E0-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B62C7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B62CA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B62E1-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B62C8-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Emedastine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B62D7-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B62D8-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B62D2-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B62D3-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B62D5-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B62D4-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B62D6-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Ophthalmic use of emedastine usually does not produce measurable plasma concentrations. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	87233-61-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Emadine 0.05% eye drops Emadine 0.05% Solution 5ml Bottle
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B62DC-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B62DE-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B62DF-363D-11E5-9242-09173F13E4C5
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http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B62DA-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B62DD-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B62CC-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B62D9-363D-11E5-9242-09173F13E4C5

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