| Attributes | Values |
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| rdf:type
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| http://linked.open...gbank/description
| - Dimenhydrinate (Dramamine, Gravol and Vertirosan) is an over-the-counter drug used to prevent motion sickness. It is closely related to diphenhydramine HCl, or Benadryl. It is primarily a H1-antagonist, but also possesses an antimuscarinic effect. (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Takeda N, Morita M, Hasegawa S, Horii A, Kubo T, Matsunaga T: Neuropharmacology of motion sickness and emesis. A review. Acta Otolaryngol Suppl. 1993;501:10-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8447218 # Halpert AG, Olmstead MC, Beninger RJ: Mechanisms and abuse liability of the anti-histamine dimenhydrinate. Neurosci Biobehav Rev. 2002 Jan;26(1):61-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11835984 # Jaju BP, Wang SC: Effects of diphenhydramine and dimenhydrinate on vestibular neuronal activity of cat: a search for the locus of their antimotion sickness action. J Pharmacol Exp Ther. 1971 Mar;176(3):718-24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4329456 (en)
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| http://linked.open...gy/drugbank/group
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| http://linked.open...drugbank/halfLife
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| http://linked.open...ugbank/indication
| - Used for treating vertigo, motion sickness, and nausea associated with pregnancy. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - The mechanism by which some antihistamines exert their antiemetic, anti–motion sickness, and antivertigo effects is not precisely known but may be related to their central anticholinergic actions. They diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Dimenhydrinate is a competitive antagonist at the histamine H1 receptor, which is widely distributed in the human brain. Dimenhydrinate's anti-emetic effect is probably due to H1 antagonism in the vestibular system in the brain. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open.../drugbank/synonym
| - Diphenhydrinate (en)
- N,N-Dimethyl-2-diphenylmethoxyethylamine 8-chlorotheophyllinate (en)
- O-Benzhydryldimethylaminoethanol 8-chlorotheophyllinate (en)
- Dimenhidrinato (en)
- Dimenhydrinatum (en)
- Diphenhydramine 8-chlorotheophyllinate (en)
- Diphenhydramine 8-chlorotheophylline (en)
- Diphenhydramine theoclate (en)
- beta-Dimethylaminoethyl benzhydryl ether 1,3-dimethyl-8-chloroxanthine (en)
- Benzhydryl-beta-dimethylaminoethylether 8-chlorotheophylline (en)
- (O-Benzhydryl(dimethylamino)ethanol) 8-chlorotheophyllinate (en)
- 8-chloro-1,3-Dimethyl-3,7-dihydro-1H-purine-2,6-dione - 2-(diphenylmethoxy)-N,N-dimethylethanamine (1:1) (en)
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| http://linked.open...drugbank/toxicity
| - Symptoms of overdose include delerium, hallucinations, and excitment. Patients may be violent and confused. (en)
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| http://linked.open.../drug/hasAHFSCode
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| http://linked.open...k/foodInteraction
| - Avoid alcohol. (en)
- Take with food. (en)
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| http://linked.open...nk/proteinBinding
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| http://linked.open...ynthesisReference
| - Cusic, J.W.; U.S. Patent 2,499,058; February 28,1950; assigned to G.D. Searle & Co. Cusic, J.W.; U.S. Patent 2,534,813; December 19,1950; assigned to G.D. Searle & Co. (en)
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| foaf:page
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| http://linked.open...ugbank/IUPAC-Name
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| http://linked.open...gy/drugbank/InChI
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| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
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| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
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| http://linked.open...nd-Acceptor-Count
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| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
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| http://linked.open...urface-Area--PSA-
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| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
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| http://linked.open...atable-Bond-Count
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| http://linked.open...ugbank/absorption
| - Well absorbed after oral administration. (en)
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| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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| http://linked.open...casRegistryNumber
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| http://linked.open...drugbank/category
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| http://linked.open...gbank/containedIn
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