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rdf:type
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http://linked.open...gbank/description
| - A dopamine D1 receptor agonist that is used as an antihypertensive agent. It lowers blood pressure through arteriolar vasodilation. [PubChem] (en)
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http://linked.open...y/drugbank/dosage
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http://linked.open...gy/drugbank/group
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http://linked.open...drugbank/halfLife
| - The elimination half-life is about 5 minutes in mild to moderate hypertensives, with little difference between the R (active) and S isomers. (en)
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http://linked.open...ugbank/indication
| - For the in-hospital, short-term (up to 48 hours) management of severe hypertension when rapid, but quickly reversible, emergency reduction of blood pressure is clinically indicated, including malignant hypertension with deteriorating end-organ function. (en)
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http://linked.open...bank/manufacturer
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sameAs
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Title
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adms:identifier
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http://linked.open...mechanismOfAction
| - Fenoldopam is a rapid-acting vasodilator. It is an agonist for D<sub>1</sub>-like dopamine receptors and binds with moderate affinity to α<sub>2</sub>-adrenoceptors. It has no significant affinity for D<sub>2</sub>-like receptors, α<sub>1</sub> and β-adrenoceptors, 5<sub>HT1</sub> and 5<sub>HT2</sub> receptors, or muscarinic receptors. Fenoldopam is a racemic mixture with the R-isomer responsible for the biological activity. The R-isomer has approximately 250-fold higher affinity for D<sub>1</sub>-like receptors than does the S-isomer. In non-clinical studies, fenoldopam had no agonist effect on presynaptic D<sub>2</sub>-like dopamine receptors, or α or β -adrenoceptors, nor did it affect angiotensin-converting enzyme activity. Fenoldopam may increase norepinephrine plasma concentration. (en)
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http://linked.open...drugbank/packager
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http://linked.open...outeOfElimination
| - Radiolabeled studies show that about 90% of infused fenoldopam is eliminated in urine, 10% in feces. Elimination is largely by conjugation, without participation of cytochrome P-450 enzymes. Only 4% of the administered dose is excreted unchanged. (en)
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http://linked.open.../drugbank/synonym
| - Fenoldopam (en)
- Fenoldopamum (en)
- FĂ©noldopam (en)
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http://linked.open...drugbank/toxicity
| - The most likely reaction of overdose would be excessive hypotension which should be treated with drug discontinuation and appropriate supportive measures. (en)
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http://linked.open...ogy/drugbank/salt
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http://linked.open...ynthesisReference
| - "DrugSyn.org":http://www.drugsyn.org/Fenoldopam.htm (en)
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foaf:page
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http://linked.open...ugbank/IUPAC-Name
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http://linked.open...gy/drugbank/InChI
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http://linked.open...Molecular-Formula
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http://linked.open.../Molecular-Weight
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http://linked.open...noisotopic-Weight
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http://linked.open...y/drugbank/SMILES
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http://linked.open.../Water-Solubility
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http://linked.open...ogy/drugbank/logP
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http://linked.open...ogy/drugbank/logS
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http://linked.open...l/drug/hasATCCode
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http://linked.open...nd-Acceptor-Count
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http://linked.open...-Bond-Donor-Count
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http://linked.open...drugbank/InChIKey
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http://linked.open...urface-Area--PSA-
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http://linked.open...nk/Polarizability
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http://linked.open...bank/Refractivity
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http://linked.open...atable-Bond-Count
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http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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http://linked.open...casRegistryNumber
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http://linked.open...drugbank/category
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http://linked.open...gbank/containedIn
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http://linked.open...k/Bioavailability
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http://linked.open...bank/Ghose-Filter
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http://linked.open...nk/MDDR-Like-Rule
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http://linked.open...k/Number-of-Rings
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http://linked.open...siological-Charge
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http://linked.open...bank/Rule-of-Five
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http://linked.open...tional-IUPAC-Name
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http://linked.open...strongest-acidic-
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http://linked.open...-strongest-basic-
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