About: Procaine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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http://linked.open...gbank/description	A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). [PubChem] (en)
http://linked.open...generalReferences	# Gentry CL, Lukas RJ: Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11714893 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	7.7 minutes (en)
http://linked.open...ugbank/indication	Used as a local anesthetic primarily in oral surgery (en)
http://linked.open...bank/manufacturer	Eli lilly and co Consolidated pharmaceutical group inc King pharmaceuticals inc Parke davis div warner lambert co Pfizer laboratories div pfizer inc Hospira inc Abraxis pharmaceutical products Bel mar laboratories inc Elkins sinn div ah robins co inc Gd searle llc Miles laboratories inc Watson laboratories inc
sameAs	Procaine
Title	Procaine (en)
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http://linked.open...mechanismOfAction	Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex. (en)
http://linked.open...drugbank/packager	APP Pharmaceuticals Hospira Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Lannett co inc Eli lilly and co Halsey drug co inc Merck and co inc Abbott laboratories pharmaceutical products div Pharmax group inc Pharmeral inc
http://linked.open...outeOfElimination	With normal kidney function, the drug is excreted rapidly by tubular excretion. (en)
http://linked.open.../drugbank/synonym	Procaine (en) Novocaine (en) Vitamin H3 (en) 2-Diethylaminoethyl p-aminobenzoate (en) 4-Aminobenzoic acid 2-diethylaminoethyl ester (en) Procaina (en) Procainum (en) beta-(Diethylamino)ethyl 4-aminobenzoate (en) beta-(Diethylamino)ethyl P-aminobenzoate (en) p-Aminobenzoic acid 2-diethylaminoethyl ester (en) β-(diethylamino)ethyl 4-aminobenzoate (en) β-(diethylamino)ethyl p-aminobenzoate (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/24-04-04-04 http://linked.opendata.cz/resource/AHFS/72-00-00
http://linked.open...ogy/drugbank/salt	(en)
foaf:page	http://www.drugs.com/mtm/procaine.html
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http://linked.open...l/drug/hasATCCode	Procaine Procaine Procaine
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	59-46-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Folvite 5 mg/ml vial Folic acid powder Folic Acid 5 mg/ml Capozide 50-15 mg tablet CVS Pharmacy folic acid 800 mcg tablet Capozide 50-25 tablet Folic acid 0.8 mg tablet Capozide 25-25 tablet Accuretic 20-12.5 mg tablet CVS Pharmacy decongestant 30 mg tablet
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