About: Benzyl Benzoate     Goto   Sponge   Distinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties. (en)
http://linked.open...generalReferences
  • # Bachewar NP, Thawani VR, Mali SN, Gharpure KJ, Shingade VP, Dakhale GN: Comparison of safety, efficacy, and cost effectiveness of benzyl benzoate, permethrin, and ivermectin in patients of scabies. Indian J Pharmacol. 2009 Feb;41(1):9-14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20177574 # Buffet M, Dupin N: Current treatments for scabies. Fundam Clin Pharmacol. 2003 Apr;17(2):217-25. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12667233 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • Used to kill lice and the mites responsible for the skin condition scabies. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Benzyl Benzoate (en)
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http://linked.open...mechanismOfAction
  • Benzyl benzoate exerts toxic effects on the nervous system of the parasite, resulting in its death. It is also toxic to mite ova, though its exact mechanism of action is unknown. In vitro, benzyl benzoate has been found to kill the Sarcoptes mite within 5 minutes. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Benylate (en)
  • Benzoic acid, benzyl ester (en)
  • Benzoic acid, phenylmethyl ester (en)
  • Acarobenzyl (en)
  • BENZOIC acid phenylmethylester (en)
  • Benzevan (en)
  • Benzoate de benzyle (en)
  • Benzoesäurebenzylester (en)
  • Benzyl benzoat (en)
  • Benzylis benzoas (en)
  • Phenylmethyl benzoate (en)
  • Spasmodine (en)
http://linked.open...drugbank/toxicity
  • Oral, rabbit: LD<sub>50</sub> = 1680 mg/kg; Skin, rabbit: LD<sub>50</sub> = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness. (en)
http://linked.open.../drugbank/mixture
http://linked.open...ynthesisReference
  • Henri Sidi, William G. Hughes, "Process for the production of benzoic acid from process residues that contain benzyl benzoate." U.S. Patent US4281178, issued September, 1941. (en)
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http://linked.open...ugbank/IUPAC-Name
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http://linked.open.../Water-Solubility
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http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified. (en)
http://linked.open.../affectedOrganism
  • Sarcoptes scabiei (en)
http://linked.open...casRegistryNumber
  • 120-51-4 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...ank/Boiling-Point
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...-strongest-basic-
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