About: Dextropropoxyphene

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Dextropropoxyphene is an analgesic in the opioid category, patented (1955) and manufactured by Eli Lilly and Company. It is intended to treat mild pain and also has antitussive and local anaesthetic effects. The drug has been taken off the market in Europe and the US due to concerns of fatal overdoses and heart arrhythmias. An estimated 10 million patients have used these products. The drug is often referred to as the general form, "propoxyphene", however only the dextro-isomer (dextropropoxyphene) has any analgesic effect. The levo-isomer appears to exhibit a very limited antitussive effect. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B60EB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B60EC-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Coda BA, Rudy AC, Archer SM, Wermeling DP: Pharmacokinetics and bioavailability of single-dose intranasal hydromorphone hydrochloride in healthy volunteers. Anesth Analg. 2003 Jul;97(1):117-23, table of contents. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12818953 (en)
http://linked.open...gy/drugbank/group	approved (en) illicit (en) withdrawn (en)
http://linked.open...drugbank/halfLife	6-12 hours (en)
http://linked.open...ugbank/indication	For the relief of mild to moderate pain (en)
http://linked.open...bank/manufacturer	Remedy Repack Heritage pharmaceuticals inc Mk laboratories inc Halsey drug co inc Alra laboratories inc Impax laboratories inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Mutual pharmaceutical co inc Valeant pharmaceuticals international Vintage pharmaceuticals inc Watson laboratories inc West ward pharmaceutical corp Whiteworth towne paulsen inc Warner chilcott div warner lambert co Aaipharma llc Amend Apothecon Baxter International Inc. Minrad Inc. Private formulations inc Abbott laboratories hosp products div Sandoz inc Baxter healthcare corp anesthesia critical care
sameAs	Dextropropoxyphene
Title	Dextropropoxyphene (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00647/identifier/drugbank/DB00647 http://linked.opendata.cz/resource/drugbank/drug/DB00647/identifier/kegg-compound/C07406 http://linked.opendata.cz/resource/drugbank/drug/DB00647/identifier/national-drug-code-directory/0378-7065-01 http://linked.opendata.cz/resource/drugbank/drug/DB00647/identifier/pharmgkb/PA451142 http://linked.opendata.cz/resource/drugbank/drug/DB00647/identifier/chebi/51173 http://linked.opendata.cz/resource/drugbank/drug/DB00647/identifier/kegg-drug/D07809 http://linked.opendata.cz/resource/drugbank/drug/DB00647/identifier/wikipedia/Propoxyphene
http://linked.open...mechanismOfAction	Propoxyphene acts as a weak agonist at OP1, OP2, and OP3 opiate receptors within the central nervous system (CNS). Propoxyphene primarily affects OP3 receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited. Opioids such as propoxyphene also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (OP3 and OP1 receptor agonist). This results in hyperpolarization and reduced neuronal excitability. (en)
http://linked.open...drugbank/packager	Cardinal Health Carlisle Laboratories Inc. Chattem Chemicals Inc. Concord Labs Consolidated Midland Corp. Contract Pharm CVS Pharmacy Darby Dental Supply Co. Inc. Dept Health Central Pharmacy Actavis mid atlantic llc DispenseXpress Inc. Dispensing Solutions Diversified Healthcare Services Inc. Eon Labs Equaline Vitamins Eisai Inc. General Injectables and Vaccines Inc. GlaxoSmithKline Inc. Goldline Laboratories Inc. Heartland Repack Services LLC Hospira Inc. Innoviant Pharmacy Inc. Akorn Inc. Allergan Inc. Apotex Inc. Bausch & Lomb Inc. Major Pharmaceuticals Martin Surgical Supply McNeil Laboratories Medique Products Bausch and lomb inc Akorn inc Alcon inc Apotex inc etobicoke site Murfreesboro Pharmaceutical Nursing Supply Nexgen Pharma Inc. North Safety Products Nucare Pharmaceuticals Inc. Patient First Corp. PCA LLC PD-Rx Pharmaceuticals Inc. Perrigo Co. Pfizer Inc. Pharmaceutical Association Pharmedix Physicians Total Care Inc. Poly Pharmaceuticals Inc. Patheon Inc. Prepackage Specialists Prepak Systems Inc. Prescript Pharmaceuticals Procter & Gamble Provident Pharmaceuticals LLC AAIPharma Inc. Aidarex Pharmacuticals LLC Altura Pharmaceuticals Inc. Amerisource Health Services Corp.

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