About: Simvastatin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Simvastatin is a lipid-lowering agent that is derived synthetically from the fermentation of Aspergillus terreus. It is a potent competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (hydroxymethylglutaryl COA reductases), which is the rate-limiting enzyme in cholesterol biosynthesis. It may also interfere with steroid hormone production. Due to the induction of hepatic LDL receptors, it increases breakdown of LDL cholesterol. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5F01-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F02-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F03-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F04-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F05-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F06-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F07-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F08-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F09-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5F0A-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Wolozin B, Wang SW, Li NC, Lee A, Lee TA, Kazis LE: Simvastatin is associated with a reduced incidence of dementia and Parkinson's disease. BMC Med. 2007 Jul 19;5:20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17640385 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3 hours (en)
http://linked.open...ugbank/indication	For the treatment of hypercholesterolemia and for the reduction in the risk of cardiac heart disease mortality and cardiovascular events. It can also be used in adolescent patients for the treatment of heterozygous familial hypercholesterolemia. (en)
http://linked.open...bank/manufacturer	Liberty Pharmaceuticals Accord healthcare inc Aurobindo pharma ltd Pharmaceutical Utilization Management Program VA Inc. Alcon inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Lupin ltd Hr cenci laboratories inc Baxter healthcare corp anesthesia critical care PD-Rx Pharmaceuticals Inc. Merck and co inc Preferred Pharmaceuticals Inc. Prepackage Specialists Merck research laboratories div merck co inc
sameAs	Simvastatin
Title	Simvastatin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00641/identifier/chebi/9150 http://linked.opendata.cz/resource/drugbank/drug/DB00641/identifier/drugbank/DB00641 http://linked.opendata.cz/resource/drugbank/drug/DB00641/identifier/kegg-drug/D00434 http://linked.opendata.cz/resource/drugbank/drug/DB00641/identifier/national-drug-code-directory/16714-681-01 http://linked.opendata.cz/resource/drugbank/drug/DB00641/identifier/pdb/SIM http://linked.opendata.cz/resource/drugbank/drug/DB00641/identifier/pharmgkb/PA451363 http://linked.opendata.cz/resource/drugbank/drug/DB00641/identifier/wikipedia/Simvastatin
http://linked.open...mechanismOfAction	Simvastatin is a prodrug in which the 6-membered lactone ring of simvastatin is hydrolyzed <i>in vivo</i> to generate the beta,delta-dihydroxy acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol. (en)
http://linked.open...drugbank/packager	Ah robins co Abbott Laboratories Ltd. Accord Healthcare Advanced Pharmaceutical Services Inc. DAVA Pharmaceuticals Amerisource Health Services Corp. AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Aurobindo Pharma Ltd. Blenheim Pharmacal Blu Pharmaceuticals LLC Sandoz Cadila Healthcare Ltd. Cardinal Health Cobalt Pharmaceuticals Inc. Comprehensive Consultant Services Inc. Corepharma LLC Coupler Enterprises Inc. Pharmaceutical Utilization Management Program VA Inc. Apotex inc Direct Dispensing Inc. Cadista pharmaceuticals inc Diversified Healthcare Services Inc. Doctor Reddys Laboratories Ltd. Intas Pharmaceuticals Ltd. Kaiser Foundation Hospital Boehringer Ingelheim Ltd. Cardinal Health Kaiser Foundation Hospital Lake Erie Medical and Surgical Supply Mallinckrodt Inc. Mckesson Corp. Medisca Inc. Aurobindo pharma ltd inc Actavis Group Aidarex Pharmacuticals LLC Alphapharm Party Ltd. Apotex Inc. Apotheca Inc. A-S Medication Solutions LLC Barr Pharmaceuticals Bryant Ranch Prepack Caraco Pharmaceutical Labs Cardinal Health Caremark LLC Pharmaceutical Utilization Management Program VA Inc. Barr Pharmaceuticals Bryant Ranch Prepack Comprehensive Consultant Services Inc. Advanced Pharmaceutical Services Inc. Alcon Laboratories A-S Medication Solutions LLC Bayer Healthcare Cardinal Health Dispensing Solutions Sandoz Fresenius Kabi AB Goldline Laboratories Inc. H.J. Harkins Co. Inc.

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