| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - A nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA which leads to the gradual inhibition of monoamine oxidase. (From Martindale, The Extra Pharmacopoeia, 30th ed, p514) (en)
|
| http://linked.open...gy/drugbank/group
| |
| http://linked.open...drugbank/halfLife
| |
| http://linked.open...ugbank/indication
| - For the specific and symptomatic treatment of bacterial or protozoal diarrhea and enteritis caused by susceptible organisms. (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Furazolidone and its related free radical products are believed to bind DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug leading to high levels of mutations (transitions and transversions) in the bacterial chromosome. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open.../drugbank/synonym
| - Furazolidone (en)
- Furoxone (en)
- Nitrofurazolidone (en)
- Nitrofurazolidonum (en)
- 3-{[(5-nitro-2-furanyl)methylene]amino}-2-oxazolidinone (en)
- 3-(5'-Nitrofurfuralamino)-2-oxazolidone (en)
- 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidinone (en)
- 3-[(5-Nitrofurfurylidene)amino]-2-oxazolidone (en)
- 3-[(5-Nitrofurylidene)amino]-2-oxazolidone (en)
- 5-Nitro-N-(2-oxo-3-oxazolidinyl)-2-furanmethanimine (en)
- FZL (en)
- Furazolidona (en)
- Furazolidonum (en)
- N-(5-Nitro-2-furfurylidene)-3-amino-2-oxazolidone (en)
- N-(5-Nitro-2-furfurylidene)-3-aminooxazolidine-2-one (en)
|
| http://linked.open...drugbank/toxicity
| - Reactions to Furoxone have been reported including a fall in blood pressure, urticaria, fever, arthralgia, and a vesicular morbilliform rash. Other adverse effects can include a brown discoloration of the urine; hemolysis can occur in G6PDH-deficient patients. The drug has a monoamine oxidase (MAO) inhibitory effect and should never be given concurrently to individuals already taking MAO inhibitors. (en)
|
| http://linked.open...ynthesisReference
| - Drake, G.D., Gever, G. and Hayes, K.J.; U.S. Patent 2,759,931; August 21, 1956; assigned to The Norwich Pharmacal Company. Gever, G. and O'Keefe, C.J.; U.S. Patent 2,927,l IO; March 1, 1960; assigned to The Norwich Pharmacal Company. (en)
|
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - Radiolabeled drug studies indicate that furazolidone is well absorbed following oral administration (en)
|
| http://linked.open.../affectedOrganism
| - Microbes (bacteria, parasites) (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...gbank/containedIn
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
| |
| http://linked.open...ank/Melting-Point
| |
| http://linked.open...k/Number-of-Rings
| |
| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...-strongest-basic-
| |
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