About: Ethosuximide

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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http://linked.open...gbank/description	An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5222-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5223-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5224-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Patsalos PN: Properties of antiepileptic drugs in the treatment of idiopathic generalized epilepsies. Epilepsia. 2005;46 Suppl 9:140-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16302888 # Coulter DA, Huguenard JR, Prince DA: Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. Neurosci Lett. 1989 Mar 13;98(1):74-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2710401 # Coulter DA, Huguenard JR, Prince DA: Characterization of ethosuximide reduction of low-threshold calcium current in thalamic neurons. Ann Neurol. 1989 Jun;25(6):582-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2545161 # Coulter DA, Huguenard JR, Prince DA: Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br J Pharmacol. 1990 Aug;100(4):800-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2169941 # Kostyuk PG, Molokanova EA, Pronchuk NF, Savchenko AN, Verkhratsky AN: Different action of ethosuximide on low- and high-threshold calcium currents in rat sensory neurons. Neuroscience. 1992 Dec;51(4):755-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/1336826 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	53 hours (en)
http://linked.open...ugbank/indication	For the treatment of petit mal epilepsy. (en)
http://linked.open...bank/manufacturer	Aidarex Pharmacuticals LLC Apotheca Inc. A-S Medication Solutions LLC Abraxis pharmaceutical products Astrazeneca lp Camber Pharmaceuticals Inc. Cardinal Health
sameAs	Ethosuximide
Title	Ethosuximide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/bindingdb/50240424 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/chebi/4887 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/chemspider/3175 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/drugbank/DB00593 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/kegg-compound/C07505 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/kegg-drug/D00539 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/national-drug-code-directory/0071-0237-24 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/pharmgkb/PA449533 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/pubchem-compound/3291 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/pubchem-substance/46507617 http://linked.opendata.cz/resource/drugbank/drug/DB00593/identifier/wikipedia/Ethosuximide
http://linked.open...mechanismOfAction	Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. (en)
http://linked.open...drugbank/packager	Amerisource Health Services Corp. Barr Pharmaceuticals Catalent Pharma Solutions Mikart Inc. Pfizer Inc. Akorn Inc. American Regent Cardinal Health Hospira Inc.
http://linked.open.../drugbank/synonym	Ethosuximide (en) Atysmal (en) Thilopemal (en) Aethosuximide (en) Etosuximida (en) (+-)-2-Ethyl-2-methylsuccinimide (en) (±)-2-ethyl-2-methylsuccinimide (en) 2-Methyl-2-ethylsuccinimide (en) 2-ethyl-2-methylsuccinimide (en) 3-Ethyl-3-methylsuccinimide (en) 3-Methyl-3-ethylpyrrolidine-2,5-dione (en) 3-Methyl-3-ethylsuccinimide (en) 3-ethyl-3-methyl-2,5-pyrrolidinedione (en) Ethosuximid (en) Ethosuximidum (en) alpha-Ethyl-alpha-methylsuccinimide (en) alpha-Methyl-alpha-ethylsuccinimide (en) gamma-Ethyl-gamma-methyl-succinimide (en) gamma-Methyl-gamma-ethyl-succinimide (en) γ-ethyl-γ-methyl-succinimide (en)
http://linked.open...drugbank/toxicity	Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/28-12-20
http://linked.open...k/foodInteraction	Avoid alcohol. (en) Take with food. (en)
http://linked.open...ynthesisReference	Miller, C.A. and Long, L.M.; U.S. Patent 2,993,835; July 25,1961; assigned to Parke, Davis and Company. (en)
foaf:page	http://www.drugs.com/cdi/ethosuximide.html http://www.rxlist.com/cgi/generic/ethosuximide.htm
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http://linked.open...l/drug/hasATCCode	Ethosuximide
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http://linked.open...ugbank/absorption	Bioavailability following oral administration is 93%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	77-67-8 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Evoclin 1% Foam 50 gm Can Acetaminophen 120 mg suppository Apap-butalbital 325-50 tablet Acetaminophen 650 mg suppository Dalacin C Palmitate 15 mg/ml Solution
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