About: Benzthiazide

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About: Benzthiazide Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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http://linked.open...gbank/description	Benzthiazide is used to treat hypertension and edema. Like other thiazides, benzthiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of high blood pressure and management of edema. (en)
http://linked.open...bank/manufacturer	Central Texas Community Health Centers Clonmel Healthcare Ltd. DAVA Pharmaceuticals Boehringer ingelheim pharmaceuticals inc
sameAs	Benzthiazide
Title	Benzthiazide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/chebi/3047 http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/chemspider/2253 http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/drugbank/DB00562 http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/kegg-compound/C07759 http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/kegg-drug/D00651 http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/pubchem-compound/2343 http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/pubchem-substance/46506752 http://linked.opendata.cz/resource/drugbank/drug/DB00562/identifier/pharmgkb/PA164776841
http://linked.open...mechanismOfAction	As a diuretic, benzthiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like benzthiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of benzthiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. (en)
http://linked.open.../drugbank/synonym	Benzthiazide (en) Benzothiazide (en) Benzotiazida (en) Benzthiazid (en) Benzthiazidum (en) Benztiazide (en) 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide (en) 6-chloro-1,1-dioxo-3-(Phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide (en) 3-((Benzylthio)methyl)-6-chloro-7-sulfamoyl-2H-benzo-1,2,4-thiadiazine 1,1-dioxide (en) 6-chloro-7-Sulfamoyl-3-benzylthiomethyl-2H-1,2,4-benzothiadiazine 1,1-dioxide (en) 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include nausea, vomiting, fatigue, urinary problems and drowsiness. (en)
http://linked.open.../drugbank/mixture	Dyrenium compositum Dytide
http://linked.open...nk/proteinBinding	30% (en)
http://linked.open...ynthesisReference	Samuel M. Fainberg, Porfirio F. Perez, "Stable solution of benzthiazide (3-[benzythiol methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide) suitable for parenteral administration and process of preparation." U.S. Patent US4022894, issued May 10, 1977. (en)
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http://linked.open...ugbank/absorption	Absorbed in the digestive tract. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	91-33-8 (en)
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