About: Tolmetin     Goto   Sponge   Distinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type
http://linked.open...gbank/description
  • A non-steroidal anti-inflammatory agent (anti-inflammatory agents, NON-steroidal) similar in mode of action to indomethacin. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • Biphasic elimination from the plasma consisting of a rapid phase with a half-life of one to 2 hours followed by a slower phase with a half-life of about 5 hours. (en)
http://linked.open...ugbank/indication
  • For the relief of signs and symptoms of rheumatoid arthritis and osteoarthritis, including the treatment of acute flares long-term management. Also for treatment of juvenile rheumatoid arthritis. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Tolmetin (en)
adms:identifier
http://linked.open...mechanismOfAction
  • The mode of action of tolmetin is not known. However, studies in laboratory animals and man have demonstrated that the anti-inflammatory action of tolmetin is not due to pituitary-adrenal stimulation. Tolmetin inhibits prostaglandin synthetase in vitro and lowers the plasma level of prostaglandin E in man. This reduction in prostaglandin synthesis may be responsible for the anti-inflammatory action. Tolmetin does not appear to alter the course of the underlying disease in man. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Tolmetin (en)
  • 1-Methyl-5-(4-methylbenzoyl)-pyrrole-2-acetic acid (en)
  • 1-Methyl-5-P-toluoylpyrrole-2-acetic acid (en)
  • 5-(P-Toluoyl)-1-methylpyrrole-2-acetic acid (en)
  • Tolmetina (en)
  • Tolmetino (en)
  • Tolmetinum (en)
  • Tolmétine (en)
http://linked.open...drugbank/toxicity
  • Symptoms of overdose include lethargy, drowsiness, nausea, vomiting, and epigastric pain. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
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http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
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http://linked.open...drugbank/InChIKey
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http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Rapidly and almost completely absorbed with peak plasma levels being reached within 30-60 minutes after an oral therapeutic dose. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 26171-23-3 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
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http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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