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| http://linked.open...gbank/description
| - The major progestational steroid that is secreted primarily by the corpus luteum and the placenta. Progesterone acts on the uterus, the mammary glands, and the brain. It is required in embryo implantation, pregnancy maintenance, and the development of mammary tissue for milk production. Progesterone, converted from pregnenolone, also serves as an intermediate in the biosynthesis of gonadal steroid hormones and adrenal corticosteroids. [PubChem] (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Allen WM: THE ISOLATION OF CRYSTALLINE PROGESTIN. Science. 1935 Aug 2;82(2118):89-93. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17747122 # Allen WM: Progesterone: how did the name originate? South Med J. 1970 Oct;63(10):1151-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4922128 # Schumacher M, Guennoun R, Robert F, Carelli C, Gago N, Ghoumari A, Gonzalez Deniselle MC, Gonzalez SL, Ibanez C, Labombarda F, Coirini H, Baulieu EE, De Nicola AF: Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm IGF Res. 2004 Jun;14 Suppl A:S18-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15135772 # Hould FS, Fried GM, Fazekas AG, Tremblay S, Mersereau WA: Progesterone receptors regulate gallbladder motility. J Surg Res. 1988 Dec;45(6):505-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3184927 (en)
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| http://linked.open...gy/drugbank/group
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| http://linked.open...drugbank/halfLife
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| http://linked.open...ugbank/indication
| - For progesterone supplementation or replacement as part of an Assisted Reproductive Technology (ART) treatment for infertile women with progesterone deficiency and for the treatment of secondary amenorrhea. Also used for the reduction of the incidence of endometrial hyperplasia and the attendant risk of endometrial carcinoma in postmenopausal women receiving estrogen replacement therapy, as well as treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology such as fibroids or uterine cancer. (en)
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| http://linked.open...bank/manufacturer
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| http://linked.open...mechanismOfAction
| - Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open...y/drugbank/patent
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| http://linked.open...outeOfElimination
| - The glucuronide and sulfate conjugates of pregnanediol and pregnanolone are excreted in the urine and bile. Progesterone metabolites which are excreted in the bile may undergo enterohepatic recycling or may be excreted in the feces. Progesterone metabolites are excreted mainly by the kidneys. (en)
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| http://linked.open.../drugbank/synonym
| - Progesterone (en)
- Agolutin (en)
- Crinone (en)
- Corpus Luteum Hormone (en)
- Progesteronum (en)
- Pregn-4-ene-3,20-dione (en)
- (S)-4-Pregnene-3,20-dione (en)
- (S)-Pregn-4-en-3,20-dione (en)
- (S)-Progesterone (en)
- 17alpha-Progesterone (en)
- 17α-progesterone (en)
- 4-Pregnene-3,20-dione (en)
- Akrolutin (en)
- Gelbkoerperhormon (en)
- Luteohormone (en)
- Lutogynon (en)
- Progesteron (en)
- Progesterona (en)
- Progestérone (en)
- delta(4)-Pregnene-3,20-dione (en)
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| http://linked.open.../drug/hasAHFSCode
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| http://linked.open...k/foodInteraction
| - Avoid alcohol. (en)
- Take at the same time everyday. (en)
- Take with food. (en)
- Avoid excessive quantities of coffee or tea (Caffeine). (en)
- Increase dietary intake of magnesium, folate, vitamin B6, B12, and/or consider taking a multivitamin. (en)
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| http://linked.open.../drugbank/mixture
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| http://linked.open...nk/proteinBinding
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| http://linked.open...ynthesisReference
| - Nejib M. Nasraoui, Alain Piasco, "Derivatives of 19-nor progesterone; process for producing them and the pharmaceutical compositions incorporating them." U.S. Patent US5223492, issued May, 1971. (en)
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| foaf:page
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