About: Dexrazoxane

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About: Dexrazoxane Goto Sponge Distinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An antimitotic agent with immunosuppressive properties. Dexrazoxane, the (+)-enantiomorph of razoxane, provides cardioprotection against anthracycline toxicity. It appears to inhibit formation of a toxic iron-anthracycline complex. [PubChem] The Food and Drug Administration has designated dexrazoxane as an orphan drug for use in the prevention or reduction in the incidence and severity of anthracycline-induced cardiomyopathy. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B64A0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B64A1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B64A2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B64A3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B64A4-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Hasinoff BB, Herman EH: Dexrazoxane: how it works in cardiac and tumor cells. Is it a prodrug or is it a drug? Cardiovasc Toxicol. 2007;7(2):140-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17652819 # Hasinoff BB: The use of dexrazoxane for the prevention of anthracycline extravasation injury. Expert Opin Investig Drugs. 2008 Feb;17(2):217-23. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18230055 # Kik K, Szmigiero L: [Dexrazoxane (ICRF-187)--a cardioprotectant and modulator of action of some anticancer drugs] Postepy Hig Med Dosw (Online). 2006;60:584-90. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17115008 # Weiss G, Loyevsky M, Gordeuk VR: Dexrazoxane (ICRF-187). Gen Pharmacol. 1999 Jan;32(1):155-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9888268 # Langer SW: Dexrazoxane for anthracycline extravasation. Expert Rev Anticancer Ther. 2007 Aug;7(8):1081-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18028016 (en)
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en)
http://linked.open...drugbank/halfLife	2.5 hours (en)
http://linked.open...ugbank/indication	For reducing the incidence and severity of cardiomyopathy associated with doxorubicin administration in women with metastatic breast cancer who have received a cumulative doxorubicin hydrochloride dose of 300 mg/m^2 and would benefit from continued doxorubicin therapy. Also approved for the treatment of extravasation from intravenous anthracyclines. (en)
http://linked.open...bank/manufacturer	Bedford laboratories div ben venue laboratories inc Topotarget as Pharmacia and upjohn co
sameAs	Dexrazoxane
Title	Dexrazoxane (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/chebi/50223 http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/chemspider/64479 http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/drugbank/DB00380 http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/national-drug-code-directory/38423-110-01 http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/pdb/CDX http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/pharmgkb/PA449259 http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/pubchem-compound/71384 http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/pubchem-substance/46505982 http://linked.opendata.cz/resource/drugbank/drug/DB00380/identifier/wikipedia/Dexrazoxane
http://linked.open...mechanismOfAction	The mechanism by which dexrazoxane exerts its cardioprotective activity is not fully understood. Dexrazoxane is a cyclic derivative of EDTA that readily penetrates cell membranes. Results of laboratory studies suggest that dexrazoxane (a prodrug) is converted intracellularly to a ring-opened bidentate chelating agent that chelates to free iron and interferes with iron-mediated free radical generation thought to be responsible, in part, for anthracycline-induced cardiomyopathy. It should be noted that dexrazoxane may also be protective through its inhibitory effect on topoisomerase II. (en)
http://linked.open...drugbank/packager	Bedford Labs Astrazeneca pharmaceuticals lp Catalent Pharma Solutions Oso Biopharmaceuticals Manufacturing LLC Pharmacia Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5242901 http://linked.opendata.cz/resource/drugbank/patent/6727253
http://linked.open...outeOfElimination	Urinary excretion plays an important role in the elimination of dexrazoxane. Forty-two percent of the 500 mg/m2 dose of dexrazoxane was excreted in the urine. (en)
http://linked.open.../drugbank/synonym	Dexrazoxane (en) Dextrorazoxane (en) (+)-(S)-4,4'-Propylenedi-2,6-piperazinedione (en) (+)-1,2-Bis(3,5-dioxo-1-piperazinyl)propane (en) 4-[(2S)-2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione (en) Dexrazoxan (en) Dexrazoxano (en) Dexrazoxanum (en)
http://linked.open...drugbank/toxicity	Intraperitoneal, mouse LD<sub>10</sub> = 500 mg/kg. Intravenous, dog LD<sub>10</sub> = 2 gm/kg. (en)
http://linked.open...umeOfDistribution	* 9 to 22.6 L/m^2 (en)
http://linked.open...nk/proteinBinding	Very low (< 2%) (en)
http://linked.open...ogy/drugbank/salt	(en)
foaf:page	http://www.drugs.com/cdi/dexrazoxane.html http://www.rxlist.com/cgi/generic2/dexrazoxane.htm
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http://linked.open...ugbank/absorption	IV administration results in complete bioavailability. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	24584-09-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 7.88 L/h/m2 [dose of 50 mg/m2 Doxorubicin and 500 mg/m2 Dexrazoxane] * 6.25 L/h/m2 [dose of 60 mg/m2 Doxorubicin and 600 mg/m2 Dexrazoxane] (en)
http://linked.open...gbank/containedIn	Atacand 32 mg tablet Apo-Benztropine 2 mg Tablet Atacand hct 32-12.5 mg tablet Atacand hct 32-25 mg tablet
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