About: Cefmenoxime

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Cefmenoxime is a third-generation cephalosporin antibiotic. [Wikipedia] (en)
http://linked.open...generalReferences	# Yokota N, Koguchi M, Suzuki Y, Fukayama S, Ishihara R, Deguchi K, Oda S, Tanaka S, Nakane Y, Fukumoto T: [Antibacterial activities of cefmenoxime against recent fresh clinical isolates from patients in sinusitis] Jpn J Antibiot. 1995 May;48(5):602-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7637194 # Paladino JA, Fell RE: Pharmacoeconomic analysis of cefmenoxime dual individualization in the treatment of nosocomial pneumonia. Ann Pharmacother. 1994 Mar;28(3):384-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8193431 # Duncker GI, Reich U, Krausse R: Cefmenoxime in corneal organ culture. Ophthalmologica. 1994;208(5):262-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7816419 # Tsuchiya K, Kondo M, Kida M, Nakao M, Iwahi T, Nishi T, Noji Y, Takeuchi M, Nozaki Y: Cefmenoxime (SCE-1365), a novel broad-spectrum cephalosporin: in vitro and in vivo antibacterial activities. Antimicrob Agents Chemother. 1981 Jan;19(1):56-65. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6941742 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1 hour (en)
http://linked.open...ugbank/indication	Used to treat female gynecologic and obstetric infections caused by susceptible aerobic (including the gonococcus) and anaerobic bacteria. (en)
http://linked.open...bank/manufacturer	Corepharma LLC
sameAs	Cefmenoxime
Title	Cefmenoxime (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00267/identifier/chebi/55490 http://linked.opendata.cz/resource/drugbank/drug/DB00267/identifier/drugbank/DB00267 http://linked.opendata.cz/resource/drugbank/drug/DB00267/identifier/kegg-drug/D01739 http://linked.opendata.cz/resource/drugbank/drug/DB00267/identifier/pharmgkb/PA164750569 http://linked.opendata.cz/resource/drugbank/drug/DB00267/identifier/wikipedia/Cefmenoxime
http://linked.open...mechanismOfAction	The bactericidal activity of cefmenoxime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). Cefmenoxime is stable in the presence of a variety of b-lactamases, including penicillinases and some cephalosporinases. (en)
http://linked.open.../drugbank/synonym	Cefmenoxima (en) Cefmenoximum (en) (6R,7R)-7-[[(2e)-2-(2-amino-1,3-Thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (iupac) (en) (6R,7R)-7-((Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetamido)-3-((1-methyl-1H-5-tetraazolylthio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carbonsaeure (en)
http://linked.open...drugbank/toxicity	Information on cefmenoxime overdosage in humans is not available. However, with other b-lactam antibiotics, adverse effects following overdosage have included nausea, vomiting, epigastric distress, diarrhea, and convulsions. (en)
http://linked.open...nk/proteinBinding	50-70% (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Yasushi Morita, "Method for preventing coloration of aqueous preparations of cefmenoxime." U.S. Patent US4808577, issued November, 1985. (en)
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http://linked.open...l/drug/hasATCCode	Cefmenoxime
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http://linked.open...ugbank/absorption	Bioavailability is approximately 100% following intramuscular injection. (en)
http://linked.open.../affectedOrganism	Enteric bacteria and other eubacteria (en)
http://linked.open...casRegistryNumber	65085-01-0 (en)
http://linked.open...drugbank/category	(en)
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