About: Clotrimazole

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal cell membranes. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B411C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B411D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B411E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B411F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4120-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4121-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4122-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4123-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4124-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4125-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4126-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4127-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4128-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4129-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B412A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B412B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B412C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B412D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B412E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B412F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4130-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	2 hours (en)
http://linked.open...ugbank/indication	For the local treatment of oropharyngeal candidiasis and vaginal yeast infections, also used in fungal infections of the skin such as ringworm, athlete's foot, and jock itch. (en)
http://linked.open...bank/manufacturer	Mckesson Corp. Bayer pharmaceuticals corp Murfreesboro Pharmaceutical Nursing Supply Mylan Abbott Laboratories Ltd. Actavis Group Advanced Pharmaceutical Services Inc. Abbott laboratories CVS Pharmacy Bayer healthcare pharmaceuticals inc Diversified Healthcare Services Inc. Draxis Specialty Pharmaceuticals Inc. Ivax Pharmaceuticals
sameAs	Clotrimazole
Title	Clotrimazole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/bindingdb/31774 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/chebi/3764 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/chemspider/2710 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/drugbank/DB00257 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/guide-to-pharmacology/2330 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/iuphar/2330 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/kegg-compound/C06922 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/kegg-drug/D00282 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/national-drug-code-directory/54868-5463-0 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/pharmgkb/PA449057 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/pubchem-compound/2812 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/pubchem-substance/46507927 http://linked.opendata.cz/resource/drugbank/drug/DB00257/identifier/wikipedia/Clotrimazole
http://linked.open...mechanismOfAction	Clotrimazole interacts with yeast 14-α demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the membrane. In this way, clotrimazole inhibits ergosterol synthesis, resulting in increased cellular permeability. Clotrimazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms and the uptake of purine, impair triglyceride and/or phospholipid biosynthesis, and inhibit the movement of calcium and potassium ions across the cell membrane by blocking the ion transport pathway known as the Gardos channel. (en)
http://linked.open...drugbank/packager	Pharmaceutical Utilization Management Program VA Inc. Alza Corp. Bayer Healthcare Bergen Brunswig Cardinal Health CVS Pharmacy Claris Lifesciences Inc. Cobalt Pharmaceuticals Inc. Comprehensive Consultant Services Inc. Core Pharmaceuticals Bausch and lomb pharmaceuticals inc Apotex inc richmond hill Csl behring llc Apotex inc etobicoke site Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. Doctor Reddys Laboratories Ltd. Barr laboratories inc Dr reddys laboratories ltd Falcon Pharmaceuticals Ltd. PEDiNOL Pharmaceutical Utilization Management Program VA Inc. Goldline Laboratories Inc. H.J. Harkins Co. Inc. Hi Tech Pharmacal Co. Inc. Hikma Pharmaceuticals Hospira Inc. Resource Optimization and Innovation LLC Innoviant Pharmacy Inc. Ivax Pharmaceuticals J.B. Chemicals & Pharmaceuticals Kaiser Foundation Hospital Keltman Pharmaceuticals Inc. Schering-Plough Inc. Lake Erie Medical and Surgical Supply Lannett Co. Inc. Legacy Pharmaceuticals Packaging LLC Liberty Pharmaceuticals Major Pharmaceuticals Matrix Laboratories Ltd.
http://linked.open.../drugbank/synonym	Clotrimazole (en) 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole (en) 1-(O-Chloro-alpha,alpha-diphenylbenzyl)imidazole (en) 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole (en)

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