About: Lorazepam     Goto   Sponge   Distinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Kemper N, Poser W, Poser S: [Benzodiazepine dependence: addiction potential of the benzodiazepines is greater than previously assumed (author's transl)] Dtsch Med Wochenschr. 1980 Dec 5;105(49):1707-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7439058 # Lader M: Short-term versus long-term benzodiazepine therapy. Curr Med Res Opin. 1984;8 Suppl 4:120-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6144459 # Maltais F, Laberge F, Laviolette M: A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy. Chest. 1996 May;109(5):1195-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8625666 # Heisterkamp DV, Cohen PJ: The effect of intravenous premedication with lorazepam (ativan), pentobarbitone or diazepam on recall. Br J Anaesth. 1975 Jan;47(1):79-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/238548 # Milligan DW, Howard MR, Judd A: Premedication with lorazepam before bone marrow biopsy. J Clin Pathol. 1987 Jun;40(6):696-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3611398 # FDA label (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • Parenteral administration = 14±5 hours; Oral administration = 2 hours. (en)
http://linked.open...ugbank/indication
  • For the management of anxiety disorders, and for treatment of status epilepticus. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Lorazepam (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Lorazepam binds to an allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding potentiates the effects of the inhibitory neurotransmitter GABA, which upon binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolerization of the neuron. (en)
http://linked.open...drugbank/packager
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