About: Urofollitropin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Urofollitropin is important in the development of follicles produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility. Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B44E1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B44E2-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Goa KL, Wagstaff AJ: Follitropin alpha in infertility: a review. BioDrugs. 1998 Mar;9(3):235-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18020563 #Lexicomp. Urofollitropin. N.p., 2014. Web. 11 Nov. 2014. http://online.lexi.com.login.ezproxy.library.ualberta.ca/lco/action/doc/retrieve/docid/patch_f/797#f_pharmacology-and-pharmacokinetics (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Circulation half life of 3-4 hours, elimination half life of 35-40 hours (en)
http://linked.open...ugbank/indication	For treatment of female infertility (en)
http://linked.open...bank/manufacturer	Major Pharmaceuticals Pharmaceutical Utilization Management Program VA Inc.
sameAs	Urofollitropin
Title	Urofollitropin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00094/identifier/drugbank/DB00094 http://linked.opendata.cz/resource/drugbank/drug/DB00094/identifier/genbank/M16647 http://linked.opendata.cz/resource/drugbank/drug/DB00094/identifier/national-drug-code-directory/55566-8505-2 http://linked.opendata.cz/resource/drugbank/drug/DB00094/identifier/pharmgkb/PA451835 http://linked.opendata.cz/resource/drugbank/drug/DB00094/identifier/uniprotkb/P01225 http://linked.opendata.cz/resource/drugbank/drug/DB00094/identifier/wikipedia/Urofollitropin
http://linked.open...mechanismOfAction	FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells. (en)
http://linked.open...drugbank/packager	Cardinal Health Baroli Carlisle Laboratories Inc. Concord Labs Contract Pharm Eon Labs Glenwood Laboratories Iopharm Laboratories Inc. Amerisource Health Services Corp.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5767067
http://linked.open...outeOfElimination	Via liver and kidneys (en)
http://linked.open.../drugbank/synonym	FSH-B (en) FSH-beta (en) Follicle-stimulating hormone beta subunit (en) Follitropin beta chain precursor (en) Follicle Stimulating Hormone (en) FSH (en) Urofollitrophin (en)
http://linked.open...umeOfDistribution	Time to peak in plasma: IM: 17 hours (single dose), 11 hours (multiple doses) SubQ: 21 hours (single dose), 10 hours (multiple doses) (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/68-18-00
foaf:page	http://www.drugs.com/cdi/urofollitropin-purified.html http://www.rxlist.com/cgi/generic3/urofollitropin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B44E7-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B44E6-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Urofollitropin
http://linked.open...ugbank/absorption	74% (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	146479-72-3 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Bravelle 75 unit vial Fertinex 75 unit Solution
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B44E4-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B44E5-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B44E3-363D-11E5-9242-09173F13E4C5

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