About: Coagulation factor VIIa

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Recombinant human coagulation Factor VIIa (rFVIIa), intended for promoting hemostasis by activating the extrinsic pathway of the coagulation cascade.1 NovoSeven is a vitamin K-dependent glycoprotein consisting of 406 amino acid residues. Cloned and expressed in hamster kidney cells, the protein is catalytically active in a two-chain form. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B411C-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Blackshear PJ, Holloway PA, Alberti KG: Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine. Biochem J. 1975 Sep;150(3):379-87. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2155 # Roberts HR, Monroe DM, White GC: The use of recombinant factor VIIa in the treatment of bleeding disorders. Blood. 2004 Dec 15;104(13):3858-64. Epub 2004 Aug 24. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15328151 # Kenet G, Walden R, Eldad A, Martinowitz U: Treatment of traumatic bleeding with recombinant factor VIIa. Lancet. 1999 Nov 27;354(9193):1879. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10584732 # O'Connell KA, Wood JJ, Wise RP, Lozier JN, Braun MM: Thromboembolic adverse events after use of recombinant human coagulation factor VIIa. JAMA. 2006 Jan 18;295(3):293-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16418464 # Mayer SA, Brun NC, Begtrup K, Broderick J, Davis S, Diringer MN, Skolnick BE, Steiner T: Recombinant activated factor VII for acute intracerebral hemorrhage. N Engl J Med. 2005 Feb 24;352(8):777-85. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15728810 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For treatment of hemorrhagic complications in hemophilia A and B (en)
sameAs	Coagulation factor VIIa
Title	Coagulation factor VIIa (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/drugbank/DB00036 http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/genbank/M13232 http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/kegg-compound/C03378 http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/kegg-drug/D00172 http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/national-drug-code-directory/0169-7010-01 http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/uniprotkb/P08709 http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/pharmgkb/PA164748389 http://linked.opendata.cz/resource/drugbank/drug/DB00036/identifier/wikipedia/Factor_VII
http://linked.open...mechanismOfAction	NovoSeven activates the coagulation or clotting cascade by cleaving Factor IX and Factor X, which activates them and then leads to activation of thrombin and fibrin. (en)
http://linked.open...drugbank/packager	A-S Medication Solutions LLC
http://linked.open.../drugbank/synonym	Coagulation factor VII precursor (en) Eptacog alfa (en) Proconvertin (en) SPCA (en) Serum prothrombin conversion accelerator (en)
http://linked.open...umeOfDistribution	* 121 ± 30 mL/kg [adults] * 153 ± 29 mL/kg [children] * 280 to 290 mL/kg [congenital Factor VII deficiency] (en)
foaf:page	http://www.drugs.com/cdi/coagulation-factor-viia-recombinant.html http://www.rxlist.com/cgi/generic3/novoseven.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4121-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4120-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	9001-25-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 33 - 37 mL/h x kg [healthy] * 1375 +/- 396 mL/hr [severe hemophilia A male children] * 57.3 +/- 9.5 mL/hr/kg [severe hemophilia A male children] * 2767 +/- 385 mL/hr [severe hemophilia A men] * 37.6 +/- 13.1 mL/hr/kg [severe hemophilia A men] (en)
http://linked.open...gbank/containedIn	Lotrimin ultra 1% cream Clotrimazole insert Micatin 2% aerosol spray
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B411E-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B411F-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B411D-363D-11E5-9242-09173F13E4C5

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