About: Lepirudin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Lepirudin is identical to natural hirudin except for substitution of leucine for isoleucine at the N-terminal end of the molecule and the absence of a sulfate group on the tyrosine at position 63. It is produced via yeast cells. Bayer ceased the production of lepirudin (Refludan) effective May 31, 2012. (en)
http://linked.open...generalReferences	# Smythe MA, Stephens JL, Koerber JM, Mattson JC: A comparison of lepirudin and argatroban outcomes. Clin Appl Thromb Hemost. 2005 Oct;11(4):371-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16244762 # Tardy B, Lecompte T, Boelhen F, Tardy-Poncet B, Elalamy I, Morange P, Gruel Y, Wolf M, Francois D, Racadot E, Camarasa P, Blouch MT, Nguyen F, Doubine S, Dutrillaux F, Alhenc-Gelas M, Martin-Toutain I, Bauters A, Ffrench P, de Maistre E, Grunebaum L, Mouton C, Huisse MG, Gouault-Heilmann M, Lucke V: Predictive factors for thrombosis and major bleeding in an observational study in 181 patients with heparin-induced thrombocytopenia treated with lepirudin. Blood. 2006 Sep 1;108(5):1492-6. Epub 2006 May 11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16690967 # Lubenow N, Eichler P, Lietz T, Greinacher A: Lepirudin in patients with heparin-induced thrombocytopenia - results of the third prospective study (HAT-3) and a combined analysis of HAT-1, HAT-2, and HAT-3. J Thromb Haemost. 2005 Nov;3(11):2428-36. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16241940 # Askari AT, Lincoff AM: Antithrombotic Drug Therapy in Cardiovascular Disease. 2009 Oct; pp. 440–. ISBN 9781603272346. "Google books":http://books.google.com/books?id=iadLoXoQkWEC&pg=PA440. (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	Approximately 1.3 hours (en)
http://linked.open...ugbank/indication	For the treatment of heparin-induced thrombocytopenia (en)
http://linked.open...bank/manufacturer	Bayer healthcare pharmaceuticals inc
sameAs	Lepirudin
Title	Lepirudin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00001/identifier/drugbank/DB00001 http://linked.opendata.cz/resource/drugbank/drug/DB00001/identifier/national-drug-code-directory/50419-150-57 http://linked.opendata.cz/resource/drugbank/drug/DB00001/identifier/pharmgkb/PA450195 http://linked.opendata.cz/resource/drugbank/drug/DB00001/identifier/uniprotkb/P01050 http://linked.opendata.cz/resource/drugbank/drug/DB00001/identifier/kegg-drug/D06880 http://linked.opendata.cz/resource/drugbank/drug/DB00001/identifier/wikipedia/Lepirudin
http://linked.open...mechanismOfAction	Lepirudin forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen and initiate the clotting cascade. The inhibition of thrombin prevents the blood clotting cascade. (en)
http://linked.open...drugbank/packager	Barr Pharmaceuticals Berlex Labs
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1339104 http://linked.opendata.cz/resource/drugbank/patent/5180668
http://linked.open...outeOfElimination	Lepirudin is thought to be metabolized by release of amino acids via catabolic hydrolysis of the parent drug. About 48% of the administration dose is excreted in the urine which consists of unchanged drug (35%) and other fragments of the parent drug. (en)
http://linked.open.../drugbank/synonym	Hirudin variant-1 (en)
http://linked.open...drugbank/toxicity	In case of overdose (eg, suggested by excessively high aPTT values) the risk of bleeding is increased. (en)
http://linked.open...umeOfDistribution	* 12.2 L [Healthy young subjects (n = 18, age 18-60 years)] * 18.7 L [Healthy elderly subjects (n = 10, age 65-80 years)] * 18 L [Renally impaired patients (n = 16, creatinine clearance below 80 mL/min)] * 32.1 L [HIT patients (n = 73)] (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/20-12-04-12
foaf:page	http://www.drugs.com/cdi/lepirudin.html http://www.rxlist.com/cgi/generic/lepirudin.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3E7A-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3E79-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Lepirudin
http://linked.open...ugbank/absorption	Bioavailability is 100% following injection. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	120993-53-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 164 ml/min [Healthy 18-60 yrs] * 139 ml/min [Healthy 65-80 yrs] * 61 ml/min [renal impaired] * 114 ml/min [HIT (Heparin-induced thrombocytopenia)] (en)
http://linked.open...gbank/containedIn	Refludan 50 mg vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3E77-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3E78-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3E76-363D-11E5-9242-09173F13E4C5

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