@prefix rdf:	<http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix ns1:	<http://linked.opendata.cz/resource/drugbank/drug/> .
@prefix ns2:	<http://linked.opendata.cz/ontology/drugbank/> .
ns1:DB00040	rdf:type	ns2:Drug ;
	ns2:description	"29 residue peptide hormone. Glucagon is synthesized in a special non- pathogenic laboratory strain of Escherichia coli bacteria that has been genetically altered by the addition of the gene for glucagons"@en ;
	ns2:dosage	<http://linked.opendata.cz/resource/drugbank/dosage/271B4141-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/dosage/271B4142-363D-11E5-9242-09173F13E4C5> ;
	ns2:generalReferences	"# White CM: A review of potential cardiovascular uses of intravenous glucagon administration. J Clin Pharmacol. 1999 May;39(5):442-7. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/10234590"@en ;
	ns2:group	"approved"@en ;
	ns2:indication	"For treatment of severe hypoglycemia, also used in gastrointestinal imaging"@en ;
	ns2:manufacturer	<http://linked.opendata.cz/resource/drugbank/company/271B4139-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B4138-363D-11E5-9242-09173F13E4C5> .
@prefix owl:	<http://www.w3.org/2002/07/owl#> .
@prefix ns4:	<http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/> .
ns1:DB00040	owl:sameAs	ns4:DB00040 .
@prefix ns5:	<http://bio2rdf.org/drugbank:> .
ns1:DB00040	owl:sameAs	ns5:DB00040 .
@prefix dcterms:	<http://purl.org/dc/terms/> .
ns1:DB00040	dcterms:title	"Glucagon recombinant"@en .
@prefix adms:	<http://www.w3.org/ns/adms#> .
@prefix ns8:	<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/uniprotkb/> .
ns1:DB00040	adms:identifier	ns8:Q8MJ25 .
@prefix ns9:	<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/kegg-compound/> .
ns1:DB00040	adms:identifier	ns9:C01501 .
@prefix ns10:	<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/kegg-drug/> .
ns1:DB00040	adms:identifier	ns10:D00116 .
@prefix ns11:	<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/pharmgkb/> .
ns1:DB00040	adms:identifier	ns11:PA164779052 .
@prefix ns12:	<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/wikipedia/> .
ns1:DB00040	adms:identifier	ns12:Glucagon_recombinant .
@prefix ns13:	<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/genbank/> .
ns1:DB00040	adms:identifier	ns13:AF529185 .
@prefix ns14:	<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/drugbank/> .
ns1:DB00040	adms:identifier	ns14:DB00040 ,
		<http://linked.opendata.cz/resource/drugbank/drug/DB00040/identifier/national-drug-code-directory/0002-8031-01> ;
	ns2:mechanismOfAction	"Glucagon binds the glucagon receptor, a G protein-coupled receptor located in the plasma membrane, which then initiates a dual signaling pathway using both adenylate cyclase activation and increased intracellular calcium. Adenylate cyclase manufactures cAMP (cyclic AMP), which activates protein kinase A (cAMP-dependent protein kinase). This enzyme, in turn, activates phosphorylase kinase, which, in turn, phosphorylates glycogen phosphorylase, converting into the active form called phosphorylase A. Phosphorylase A is the enzyme responsible for the release of glucose-1-phosphate from glycogen polymers. This yields glucose molecules to be released into the blood. Glucagon receptors are found in the liver, kidney, brain and pancreatic islet cells. The glucagon mediated signals lead to an increase in insulin excretion"@en ;
	ns2:packager	<http://linked.opendata.cz/resource/drugbank/company/271B4137-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B4135-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B4136-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B4134-363D-11E5-9242-09173F13E4C5> ;
	ns2:synonym	"His-ser-glu(NH2)-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-glu(NH2)-asp-phe-val-glu(NH2)-trp-leu-met-asp(NH2)-thr"@en ,
		"Glucagone"@en ,
		"His-ser-gln-gly-thr-phe-thr-ser-asp-tyr-ser-lys-tyr-leu-asp-ser-arg-arg-ala-gln-asp-phe-val-gln-trp-leu-met-asn-thr"@en ,
		"Glucagon"@en ,
		"Glucagonum"@en ,
		"HSQGTFTSDYSKYLDSRRAQDFVQWLMNT"@en ;
	ns2:volumeOfDistribution	"* 0.25 L/kg"@en .
@prefix ns15:	<http://linked.opendata.cz/ontology/sukl/drug/> .
ns1:DB00040	ns15:hasAHFSCode	<http://linked.opendata.cz/resource/AHFS/68-22-12> .
@prefix foaf:	<http://xmlns.com/foaf/0.1/> .
ns1:DB00040	foaf:page	<http://www.drugs.com/cdi/glucagon.html> ,
		<http://www.rxlist.com/cgi/generic2/gluca.htm> ;
	ns2:Molecular-Formula	<http://linked.opendata.cz/resource/drugbank/property/271B4146-363D-11E5-9242-09173F13E4C5> ;
	ns2:Molecular-Weight	<http://linked.opendata.cz/resource/drugbank/property/271B4145-363D-11E5-9242-09173F13E4C5> .
@prefix ns17:	<http://linked.opendata.cz/resource/atc/> .
ns1:DB00040	ns15:hasATCCode	ns17:H04AA01 ;
	ns2:affectedOrganism	"Humans and other mammals"@en ;
	ns2:casRegistryNumber	"9007-92-5"@en ;
	ns2:category	"       "@en ;
	ns2:clearance	"* 13.5\u00A0 mL/min/kg [Adults with IV 1 mg]"@en ;
	ns2:containedIn	<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B413B-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B413C-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B413A-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B413F-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B4140-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B413D-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B413E-363D-11E5-9242-09173F13E4C5> ;
	ns2:Hydrophobicity	<http://linked.opendata.cz/resource/drugbank/property/271B4143-363D-11E5-9242-09173F13E4C5> ;
	ns2:Isoelectric-Point	<http://linked.opendata.cz/resource/drugbank/property/271B4144-363D-11E5-9242-09173F13E4C5> .