@prefix rdf:	<http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix ns1:	<http://linked.opendata.cz/resource/drugbank/drug/> .
@prefix ns2:	<http://linked.opendata.cz/ontology/drugbank/> .
ns1:DB00024	rdf:type	ns2:Drug ;
	ns2:description	"Thyrotropin alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit is nearly identical to that of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The alpha subunit is thought to be the effector region responsible for stimulation of adenylate cyclase (involved the generation of cAMP). The beta subunit (TSHB) is unique to TSH, and therefore determines its receptor specificity. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone."@en ;
	ns2:dosage	<http://linked.opendata.cz/resource/drugbank/dosage/271B3FF3-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/dosage/271B3FF4-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/dosage/271B3FF5-363D-11E5-9242-09173F13E4C5> ;
	ns2:generalReferences	"# Lexicomp  #Product label "@en ;
	ns2:group	"approved"@en ;
	ns2:halfLife	"25 \u00B1 10 hours"@en ;
	ns2:indication	"For detection of residueal or recurrent thyroid cancer"@en ;
	ns2:manufacturer	<http://linked.opendata.cz/resource/drugbank/company/271B3FF1-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B3FF0-363D-11E5-9242-09173F13E4C5> .
@prefix owl:	<http://www.w3.org/2002/07/owl#> .
@prefix ns4:	<http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/> .
ns1:DB00024	owl:sameAs	ns4:DB00024 .
@prefix ns5:	<http://bio2rdf.org/drugbank:> .
ns1:DB00024	owl:sameAs	ns5:DB00024 .
@prefix dcterms:	<http://purl.org/dc/terms/> .
ns1:DB00024	dcterms:title	"Thyrotropin Alfa"@en .
@prefix adms:	<http://www.w3.org/ns/adms#> .
@prefix ns8:	<http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/pharmgkb/> .
ns1:DB00024	adms:identifier	ns8:PA164746560 .
@prefix ns9:	<http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/uniprotkb/> .
ns1:DB00024	adms:identifier	ns9:P01225 .
@prefix ns10:	<http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/drugbank/> .
ns1:DB00024	adms:identifier	ns10:DB00024 ,
		<http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/national-drug-code-directory/58468-1849-4> .
@prefix ns11:	<http://linked.opendata.cz/resource/drugbank/drug/DB00024/identifier/genbank/> .
ns1:DB00024	adms:identifier	ns11:M16647 ;
	ns2:mechanismOfAction	"Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging."@en ;
	ns2:packager	<http://linked.opendata.cz/resource/drugbank/company/271B3FEE-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B3FEF-363D-11E5-9242-09173F13E4C5> ;
	ns2:patent	<http://linked.opendata.cz/resource/drugbank/patent/5840566> ;
	ns2:routeOfElimination	"kidney and liver"@en ;
	ns2:synonym	"Thyrotrophin-alfa"@en ,
		"rTSH"@en ,
		"Thyrotropin"@en ,
		"Thyrotropin-alpha"@en ,
		"Thytrophin"@en ,
		"Thyrotrophin-alpha"@en ,
		"TSH"@en ,
		"Thyrotropin-a"@en ,
		"Thyroid stimulating hormone"@en ;
	ns2:toxicity	"No difference in efficacy and toxicity between adult and geriatric patients. No studies in lactating women, pregnant women and pediatrics. Cautionary administration is advised. "@en .
@prefix ns12:	<http://linked.opendata.cz/ontology/sukl/drug/> .
ns1:DB00024	ns12:hasAHFSCode	<http://linked.opendata.cz/resource/AHFS/36-60-00> ;
	ns2:synthesisReference	"19366632"@en .
@prefix ns13:	<http://linked.opendata.cz/ontology/mesh/> .
@prefix ns14:	<http://linked.opendata.cz/resource/mesh/concept/> .
ns1:DB00024	ns13:hasConcept	ns14:M0534260 .
@prefix foaf:	<http://xmlns.com/foaf/0.1/> .
ns1:DB00024	foaf:page	<http://www.drugs.com/cdi/thyrotropin-alfa.html> ,
		<http://www.rxlist.com/cgi/generic2/thyrotropin.htm> ;
	ns2:Molecular-Formula	<http://linked.opendata.cz/resource/drugbank/property/271B3FFA-363D-11E5-9242-09173F13E4C5> ;
	ns2:Molecular-Weight	<http://linked.opendata.cz/resource/drugbank/property/271B3FF9-363D-11E5-9242-09173F13E4C5> .
@prefix ns16:	<http://linked.opendata.cz/resource/atc/> .
ns1:DB00024	ns12:hasATCCode	ns16:H01AB01 ;
	ns2:absorption	"Time to peak: Median: 10 hours (range: 3-24 hours)  After a single intramuscular injection of 0.9 mg of thyrotropin alfa: Cmax= 116+38mU/L, Tmax=22+8.5 hours. AUC=5088+1728 mU\u00B7hr/L."@en ;
	ns2:affectedOrganism	"Humans and other mammals"@en ;
	ns2:casRegistryNumber	"9002-71-5"@en ;
	ns2:category	"       "@en ;
	ns2:containedIn	<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B3FF2-363D-11E5-9242-09173F13E4C5> ;
	ns2:Hydrophobicity	<http://linked.opendata.cz/resource/drugbank/property/271B3FF7-363D-11E5-9242-09173F13E4C5> ;
	ns2:Isoelectric-Point	<http://linked.opendata.cz/resource/drugbank/property/271B3FF8-363D-11E5-9242-09173F13E4C5> ;
	ns2:Melting-Point	<http://linked.opendata.cz/resource/drugbank/property/271B3FF6-363D-11E5-9242-09173F13E4C5> .