@prefix rdf:	<http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix ns1:	<http://linked.opendata.cz/resource/drugbank/drug/> .
@prefix ns2:	<http://linked.opendata.cz/ontology/drugbank/> .
ns1:DB01025	rdf:type	ns2:Drug ;
	ns2:description	"Amlexanox is an antiallergic drug, clinically effective for atopic diseases, especially allergic asthma and rhinitis. Amlexanox as a topical paste is a well tolerated treatment of recurrent aphthous ulcers. Recurrent aphthous ulcer (RAU) is the most prevalent oral mucosal disease in humans, estimated to affect between 5% and 50% of the general population."@en ;
	ns2:generalReferences	"# Bell J: Amlexanox for the treatment of recurrent aphthous ulcers. Clin Drug Investig. 2005;25(9):555-66. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/17532700 "@en ;
	ns2:group	"approved"@en ,
		"investigational"@en ;
	ns2:halfLife	"Elimination half-life is 3.5 &plusmn; 1.1 hours."@en ;
	ns2:indication	"Used as a paste in the mouth to treat aphthous ulcers (canker sores). "@en .
@prefix owl:	<http://www.w3.org/2002/07/owl#> .
@prefix ns4:	<http://wifo5-03.informatik.uni-mannheim.de/drugbank/resource/drugs/> .
ns1:DB01025	owl:sameAs	ns4:DB01025 .
@prefix ns5:	<http://bio2rdf.org/drugbank:> .
ns1:DB01025	owl:sameAs	ns5:DB01025 .
@prefix dcterms:	<http://purl.org/dc/terms/> .
ns1:DB01025	dcterms:title	"Amlexanox"@en .
@prefix adms:	<http://www.w3.org/ns/adms#> .
@prefix ns8:	<http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/drugbank/> .
ns1:DB01025	adms:identifier	ns8:DB01025 .
@prefix ns9:	<http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/kegg-drug/> .
ns1:DB01025	adms:identifier	ns9:D01828 ,
		<http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/chebi/31205> ,
		<http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/chemspider/2076> ,
		<http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/pubchem-substance/46504508> .
@prefix ns10:	<http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/pharmgkb/> .
ns1:DB01025	adms:identifier	ns10:PA164745310 ,
		<http://linked.opendata.cz/resource/drugbank/drug/DB01025/identifier/pubchem-compound/2161> ;
	ns2:mechanismOfAction	"As a benzopyrano-bipyridine carboxylic acid derivative, amlexanox has anti-inflammatory and antiallergic properties. It inhibits chemical mediatory release of the slow-reacting substance of anaphylaxis (SRS-A) and may have antagonistic effects on interleukin-3. When cells are under stress, they release an inactive form of human fibroblast growth factor 1 (FGF-1), a potent mitogen (entity that causes mitosis). Amlexanox binds to FGF1, increasing its conformational stability, sterically blocking Cu(2+) induced oxidation which normally leads to activation of FGF-1.  "@en ;
	ns2:packager	<http://linked.opendata.cz/resource/drugbank/company/271B555F-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B5560-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B555D-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/company/271B555E-363D-11E5-9242-09173F13E4C5> ;
	ns2:patent	<http://linked.opendata.cz/resource/drugbank/patent/5362737> ;
	ns2:synonym	"Amlexanox"@en ,
		"2-Amino-7-isopropyl-5-oxo-5H-(1)benzopyrano(2,3-b)pyridine-3-carboxylic acid"@en ,
		"Amlexanoxo"@en ,
		"Amlexanoxum"@en ,
		"Amoxanox"@en .
@prefix ns11:	<http://linked.opendata.cz/ontology/mesh/> .
@prefix ns12:	<http://linked.opendata.cz/resource/mesh/concept/> .
ns1:DB01025	ns11:hasConcept	ns12:M0132876 .
@prefix foaf:	<http://xmlns.com/foaf/0.1/> .
ns1:DB01025	foaf:page	<http://www.drugs.com/cdi/amlexanox.html> ;
	ns2:IUPAC-Name	<http://linked.opendata.cz/resource/drugbank/property/271B5567-363D-11E5-9242-09173F13E4C5> ;
	ns2:InChI	<http://linked.opendata.cz/resource/drugbank/property/271B556D-363D-11E5-9242-09173F13E4C5> ;
	ns2:Molecular-Formula	<http://linked.opendata.cz/resource/drugbank/property/271B556C-363D-11E5-9242-09173F13E4C5> ;
	ns2:Molecular-Weight	<http://linked.opendata.cz/resource/drugbank/property/271B5569-363D-11E5-9242-09173F13E4C5> ;
	ns2:Monoisotopic-Weight	<http://linked.opendata.cz/resource/drugbank/property/271B556A-363D-11E5-9242-09173F13E4C5> ;
	ns2:SMILES	<http://linked.opendata.cz/resource/drugbank/property/271B556B-363D-11E5-9242-09173F13E4C5> ;
	ns2:Water-Solubility	<http://linked.opendata.cz/resource/drugbank/property/271B5565-363D-11E5-9242-09173F13E4C5> ;
	ns2:logP	<http://linked.opendata.cz/resource/drugbank/property/271B557D-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/property/271B5563-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/property/271B5566-363D-11E5-9242-09173F13E4C5> ;
	ns2:logS	<http://linked.opendata.cz/resource/drugbank/property/271B5564-363D-11E5-9242-09173F13E4C5> .
@prefix ns14:	<http://linked.opendata.cz/ontology/sukl/drug/> .
@prefix ns15:	<http://linked.opendata.cz/resource/atc/> .
ns1:DB01025	ns14:hasATCCode	ns15:R03DX01 ,
		ns15:A01AD07 ;
	ns2:H-Bond-Acceptor-Count	<http://linked.opendata.cz/resource/drugbank/property/271B5573-363D-11E5-9242-09173F13E4C5> ;
	ns2:H-Bond-Donor-Count	<http://linked.opendata.cz/resource/drugbank/property/271B5574-363D-11E5-9242-09173F13E4C5> ;
	ns2:InChIKey	<http://linked.opendata.cz/resource/drugbank/property/271B556E-363D-11E5-9242-09173F13E4C5> ;
	ns2:Polar-Surface-Area--PSA-	<http://linked.opendata.cz/resource/drugbank/property/271B556F-363D-11E5-9242-09173F13E4C5> ;
	ns2:Polarizability	<http://linked.opendata.cz/resource/drugbank/property/271B5571-363D-11E5-9242-09173F13E4C5> ;
	ns2:Refractivity	<http://linked.opendata.cz/resource/drugbank/property/271B5570-363D-11E5-9242-09173F13E4C5> ;
	ns2:Rotatable-Bond-Count	<http://linked.opendata.cz/resource/drugbank/property/271B5572-363D-11E5-9242-09173F13E4C5> ;
	ns2:absorption	"No significant absorption directly through the active ulcer. Most of the systemic absorption is via the gastrointestinal tract."@en ;
	ns2:affectedOrganism	"Humans and other mammals"@en ;
	ns2:casRegistryNumber	"68302-57-8"@en ;
	ns2:category	"       "@en ;
	ns2:containedIn	<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B5561-363D-11E5-9242-09173F13E4C5> ,
		<http://linked.opendata.cz/resource/drugbank/medicinal-product/271B5562-363D-11E5-9242-09173F13E4C5> ;
	ns2:Bioavailability	<http://linked.opendata.cz/resource/drugbank/property/271B5579-363D-11E5-9242-09173F13E4C5> ;
	ns2:Ghose-Filter	<http://linked.opendata.cz/resource/drugbank/property/271B557B-363D-11E5-9242-09173F13E4C5> ;
	ns2:MDDR-Like-Rule	<http://linked.opendata.cz/resource/drugbank/property/271B557C-363D-11E5-9242-09173F13E4C5> ;
	ns2:Number-of-Rings	<http://linked.opendata.cz/resource/drugbank/property/271B5578-363D-11E5-9242-09173F13E4C5> ;
	ns2:Physiological-Charge	<http://linked.opendata.cz/resource/drugbank/property/271B5577-363D-11E5-9242-09173F13E4C5> ;
	ns2:Rule-of-Five	<http://linked.opendata.cz/resource/drugbank/property/271B557A-363D-11E5-9242-09173F13E4C5> ;
	ns2:Traditional-IUPAC-Name	<http://linked.opendata.cz/resource/drugbank/property/271B5568-363D-11E5-9242-09173F13E4C5> ;
	ns2:pKa--strongest-acidic-	<http://linked.opendata.cz/resource/drugbank/property/271B5575-363D-11E5-9242-09173F13E4C5> ;
	ns2:pKa--strongest-basic-	<http://linked.opendata.cz/resource/drugbank/property/271B5576-363D-11E5-9242-09173F13E4C5> .