@prefix rdf: . @prefix ns1: . @prefix ns2: . ns1:DB00618 rdf:type ns2:Drug ; ns2:description "A tetracycline analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time. [PubChem]"@en ; ns2:dosage , , , ; ns2:generalReferences "# De Troyer A, Demanet JC: Correction of antidiuresis by demeclocycline. N Engl J Med. 1975 Oct 30;293(18):915-8. \"Pubmed\":http://www.ncbi.nlm.nih.gov/pubmed/170519"@en ; ns2:group "approved"@en ; ns2:halfLife "10-17 hours"@en ; ns2:indication "Used primarily to treat Lyme disease, acne, and bronchitis. Also indicated (but rarely used) to treat urinary tract infections, gum disease, malaria, and other bacterial infections such as gonorrhea and chlamydia. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. "@en ; ns2:manufacturer , , , , , , , , , , , , , , , , , , , , , , , , , , . @prefix owl: . @prefix ns4: . ns1:DB00618 owl:sameAs ns4:DB00618 . @prefix ns5: . ns1:DB00618 owl:sameAs ns5:DB00618 . @prefix dcterms: . ns1:DB00618 dcterms:title "Demeclocycline"@en . @prefix adms: . ns1:DB00618 adms:identifier . @prefix ns8: . ns1:DB00618 adms:identifier ns8:D00290 , . @prefix ns9: . ns1:DB00618 adms:identifier ns9:DB00618 . @prefix ns10: . ns1:DB00618 adms:identifier ns10:PA164745513 . @prefix ns11: . ns1:DB00618 adms:identifier ns11:Demeclocycline ; ns2:mechanismOfAction "Demeclocycline inhibits cell growth by inhibiting translation. It binds (reversibly) to the 30S and 50S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome, which impairs protein synthesis by bacteria. The binding is reversible in nature. The use in SIADH actually relies on a side-effect of tetracycline antibiotics; many may cause diabetes insipidus (dehydration due to the inability to concentrate urine). It is not completely understood why demeclocycline impairs the action of antidiuretic hormone, but it is thought that it blocks the binding of the hormone to its receptor."@en ; ns2:packager , , , , , , , , , , ; ns2:routeOfElimination "Demeclocycline hydrochloride, like other tetracyclines, is concentrated in the liver and excreted into the bile where it is found in much higher concentrations than in the blood. Following a single 150 mg dose of demeclocycline hydrochloride in normal volunteers, 44% (n = 8) was excreted in urine and 13% and 46%, respectively, were excreted in feces in two patients within 96 hours as active drug."@en ; ns2:synonym "7-Chloro-6-demethyltetracycline"@en , "Demethylchlortetracycline"@en , "Demeclociclina"@en , "DMCT"@en , "Demethylchlortetracyclin"@en , "[4S-(4alpha,4Aalpha,5aalpha,6beta,12aalpha)]-7-chloro-4-(dimethylamino)1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide"@en , "Demeclocyclinum"@en , "6-Demethyl-7-chlorotetracycline"@en , "DMCTC"@en , "Demeclocycline"@en ; ns2:toxicity "Oral, rat: LD50 = 2372 mg/kg"@en . @prefix ns12: . ns1:DB00618 ns12:hasAHFSCode ; ns2:foodInteraction "Avoid milk and multivalent ions."@en , "Take on an empty stomach."@en ; ns2:proteinBinding "41-50%"@en ; ns2:salt " "@en ; ns2:synthesisReference "McCormick, J.R.D., Hirsch, U., Jensen, E.R. and Sjolander, N.O.; U.S. Patent 2,878,289; March 17, 1959; assigned to American Cyanamid Company. Szumski, S.A.; U.S. Patent 3,012,946; December 12,1961; assigned to American Cyanamid Company. Goodman, J.J. and Matrishin, M.; U.S. Patent 3,019,172; assigned to American Cyanamid Company. Goodman, J.J.; U.S. Patent 3,050,446; August 21, 1962; assigned to American Cyanamid Company. Neidleman, S. L.; US. Patent 3,154,476; October 27,1964; assigned to Olin Mathieson Chemical Corporation."@en . @prefix ns13: . @prefix ns14: . ns1:DB00618 ns13:hasConcept ns14:M0005801 . @prefix foaf: . ns1:DB00618 foaf:page , ; ns2:IUPAC-Name ; ns2:InChI ; ns2:Molecular-Formula ; ns2:Molecular-Weight ; ns2:Monoisotopic-Weight ; ns2:SMILES ; ns2:Water-Solubility , ; ns2:logP , , ; ns2:logS , . @prefix ns16: . ns1:DB00618 ns12:hasATCCode ns16:J01AA01 , ns16:D06AA01 ; ns2:H-Bond-Acceptor-Count ; ns2:H-Bond-Donor-Count ; ns2:InChIKey ; ns2:Polar-Surface-Area--PSA- ; ns2:Polarizability ; ns2:Refractivity ; ns2:Rotatable-Bond-Count ; ns2:absorption "Tetracyclines are readily absorbed."@en ; ns2:affectedOrganism "Enteric bacteria and other eubacteria"@en ; ns2:casRegistryNumber "127-33-3"@en ; ns2:category " "@en ; ns2:clearance "* Renal cl=35 mL/min/1.73 m2"@en ; ns2:containedIn , , , ; ns2:Bioavailability ; ns2:Ghose-Filter ; ns2:MDDR-Like-Rule ; ns2:Melting-Point ; ns2:Number-of-Rings ; ns2:Physiological-Charge ; ns2:Rule-of-Five ; ns2:Traditional-IUPAC-Name ; ns2:pKa--strongest-acidic- ; ns2:pKa--strongest-basic- .