. "39578"^^ . "Z3614QOX8W"^^ . "PyrimethamineSYDTPNSC0003061" . "CHEBI:8673"^^ . . "58-14-0"^^ . "Pyrimethamine"^^ . "Pyrimethamine"^^ . "39578"^^ . "DaraprimBRNCI" . "Pharmacologic Substance"^^ . "Organic Chemical"^^ . . "One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.MSH2002_06_01" . "Pyrimethamine"^^ . "C788"^^ . "C0034283"^^ . "DaraprimSYDTPNSC0003061" . "PyrimethaminePTNCI" . "PYRIMETHAMINEPTFDAZ3614QOX8W" . . "C12H13ClN4"^^ . . . "3061"^^ . "FDA"^^ . . "A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)NCI" .