<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>CsA</n0:term-name><n0:term-group>AB</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . _:vb663682 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P330> "39201"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Pharmacologic Substance"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207> "C0010592"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2000/01/rdf-schema#label> "Cyclosporine"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#code> "C406"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Cyclosporin A</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>SangCya</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>27-400</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P368> "CHEBI:4031"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Class> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>CYCLOSPORINE</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>83HN0GTJ6D</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P319> "83HN0GTJ6D"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P210> "59865-13-3"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P322> "FDA"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Cyclosporin</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1744> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2002/07/owl#sameAs> <http://linked.opendata.cz/resource/ndfrt/ingredient/N0000007346> . _:vb663682 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2002/07/owl#sameAs> <http://linked.opendata.cz/resource/fda-spl/ingredient/83HN0GTJ6D> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P325> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>" . _:vb663683 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P303> "Prevention of bone marrow; organ transplant and stem cell rejection; graft versus host disease in patients with various conditions"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Ciclosporin</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>DTP</n0:term-source><n0:source-code>NSC0290193</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://linked.opendata.cz/ontology/mesh/hasConcept> <http://linked.opendata.cz/resource/mesh/concept/M0025279> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P350> "C62H111N11O12"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108> "Cyclosporine"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb663684 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Amino Acid, Peptide, or Protein"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Ciclosporin</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Cyclosporine</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>27-400</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>DTP</n0:term-source><n0:source-code>NSC0290193</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Cyclosporin A</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>DTP</n0:term-source><n0:source-code>NSC0290193</n0:source-code></n0:ComplexTerm>" . _:vb663684 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Neoral</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A8> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb663682 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>cyclosporine</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045187</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P303> "Prevention of bone marrow, organ transplant and stem cell rejection; graft versus host disease in patients with various conditions"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb663683 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P329> "39201"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb663684 . _:vb663682 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C46000> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>OL 27-400</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Cyclosporine</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>DCP</n0:term-source><n0:source-code>00088</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Sandimmun</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366> "Cyclosporine"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P302> "Allogenic transplants; prophylaxis of organ rejection in bone marrow; kidney; liver and heart transplants; psoriasis; rheumatoid arthritis; various diseases that involve autoimmune response"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Sandimmune</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . _:vb663683 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17573> . _:vb663684 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C45999> . _:vb663683 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R122> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C406> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P175> "290193"^^<http://www.w3.org/2001/XMLSchema#string> .