<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://linked.opendata.cz/ontology/mesh/hasConcept> <http://linked.opendata.cz/resource/mesh/concept/M0302995> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Pharmacologic Substance"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P329> "38517"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>R(+)XK469</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P330> "38517"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1968> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>The R-isomer of a synthetic quinoxaline phenoxypropionic acid derivative with proapoptotic and antiproliferative activities. R(+)XK469 selectively inhibits topoisomerase II-beta, blocks activation of MEK/MAPK signaling kinases, stimulates caspases, and upregulates p53-dependent proteins, including cyclins A and B1, thereby arresting cancer cells in the G2/M phase of the cell cycle. Both R(+) and S(-) isomers of this agent are cytotoxic, although the R-isomer is more potent. (NCI05)</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Propanoic acid, 2-[4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}-, (+ )-(R)-</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#code> "C2662"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Class> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P325> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A substance that is being studied in the treatment of leukemia. It belongs to the family of drugs called topoisomerase inhibitors.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207> "C0765292"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://www.w3.org/2000/01/rdf-schema#label> "R(+)XK469"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>2-{4-[(7-chloro-2-quinoxalinyl)oxy]phenoxy}propionic acid</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366> "XK469"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P175> "698215"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P303> "Advanced Solid Tumors or Lymphoma"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>XK469</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000045067</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2662> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108> "R(+)XK469"^^<http://www.w3.org/2001/XMLSchema#string> .