. "Clinical Drug"^^ . "A colloidal dispersion formulation of 9-Aminocamptothecin, a water-insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity.NCI" . "Aminocamptothecin Colloidal DispersionPTNCI" . "9AC colloidal dispersionSYNCI" . "Refractory or Relapsed Leukemia; Solid Tumors; Cancer Predominantly Confined to the Peritoneal Cavity."^^ . "Aminocamptothecin_Colloidal_Dispersion"^^ . . "C2452"^^ . "Aminocamptothecin Colloidal Dispersion"^^ . "Aminocamptothecin Colloidal Dispersion"^^ . "Organic Chemical"^^ . "42874"^^ . "9-aminocamptothecin colloidal dispersionSYNCI" . "42874"^^ . "C0677807"^^ .