<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://www.w3.org/2000/01/rdf-schema#label>	"L-Leucyl-L-Leucine Methyl Ester"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97>	"<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A 2-amino acid compound with immunomodulatory activity. L-leucyl-L-leucine methyl ester (LLME) is a lysosomotropic agent entering cells via receptor-mediated endocytosis. LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. Condensation of LLME leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T-cells and natural killer cells. Therefore, this agent may be able to decrease the incidence of graft versus host disease (GVHD) via cytotoxic T-cell depletion. Furthermore, LLME has the potential in augmenting antibody production when used in pretreatment of peripheral blood mononuclear cells (PBMCs), possibly via interfering gene expressions of inflammatory factors.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://www.w3.org/2000/01/rdf-schema#subClassOf>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C574> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207>	"C0281255"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P330>	"41645"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://www.w3.org/1999/02/22-rdf-syntax-ns#type>	<http://www.w3.org/2002/07/owl#Class> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366>	"L-Leucyl-L-Leucine_Methyl_Ester"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P210>	"13022-42-9"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106>	"Amino Acid, Peptide, or Protein"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P329>	"41645"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90>	"<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>LLME</n0:term-name><n0:term-group>AB</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#code>	"C2377"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90>	"<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>LeuLeuOMe</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90>	"<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>L-Leucyl-L-Leucine Methyl Ester</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106>	"Pharmacologic Substance"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2377>	<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108>	"L-Leucyl-L-Leucine Methyl Ester"^^<http://www.w3.org/2001/XMLSchema#string> .