"174280"^^ . "8RAS91C36W"^^ . "Sodium ButyratePTNCI" . "Sodium_Butyrate"^^ . "Pharmacologic Substance"^^ . "39601"^^ . "The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling.NCI" . "C4H7O2.Na"^^ . "C0142812"^^ . "butyric acid, sodium saltSYNCI" . "Sodium butyrateSYDTPNSC0174280" . "Butyric Acid, Sodium SaltPTDCP01098" . . "ButyrateSYNCI" . "156-54-7"^^ . "C2337"^^ . "sodium butanoateSYNCI" . "Butyrate sodiumSYDTPNSC0174280" . . "Sodium Butyrate"^^ . "Sodium butanoateSYDTPNSC0174280" . "Lipid"^^ . "FDA"^^ . "39601"^^ . "CHEBI:64103"^^ . "SODIUM BUTYRATEPTFDA8RAS91C36W" . . "Sodium Butyrate"^^ .