<http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Sorafenib Tosylate</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A7> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17484> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Nexavar</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000470244</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A8> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C63923> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://linked.opendata.cz/ontology/mesh/hasConcept> <http://linked.opendata.cz/resource/mesh/concept/M0493144> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A7> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26202> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A7> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26203> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P330> "299013"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Class> . _:vb648220 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R125> . _:vb648218 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40821> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A7> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17476> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A7> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17328> . _:vb648221 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R125> . _:vb648218 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/2000/01/rdf-schema#subClassOf> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1404> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P97> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>The tosylate salt of sorafenib, a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.</n0:def-definition><n0:def-source>NCI</n0:def-source></n0:ComplexDefinition>" . _:vb648219 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P350> "C21H16ClF3N4O3.C7H8O3S"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/2000/01/rdf-schema#label> "Sorafenib Tosylate"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Organic Chemical"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>BAY 43-9006 Tosylate</n0:term-name><n0:term-group>SY</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . _:vb648222 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A6> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61948> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb648218 . _:vb648218 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R125> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>BAY 54-9085</n0:term-name><n0:term-group>CN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P207> "C1676709"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Sorafenib Tosylate</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>DCP</n0:term-source><n0:source-code>32161</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P302> "Advanced renal cell carcinoma; Metastatic Colorectal Cancer"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb648219 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb648220 . _:vb648219 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C40577> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P106> "Pharmacologic Substance"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb648221 . _:vb648219 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R124> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://www.w3.org/2000/01/rdf-schema#subClassOf> _:vb648222 . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P175> "724772"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb648220 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . _:vb648222 <http://www.w3.org/2002/07/owl#onProperty> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#R146> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P210> "475207-59-1"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb648221 <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.w3.org/2002/07/owl#Restriction> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P329> "299013"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb648222 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C17484> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P108> "Sorafenib Tosylate"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P368> "CHEBI:50928"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A7> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30164> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P322> "FDA"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb648220 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20751> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>Nexavar</n0:term-name><n0:term-group>BR</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#A7> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C28496> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P366> "BAY_43-9006"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P325> "<n0:ComplexDefinition xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:def-definition>A drug used to treat advanced kidney cancer and a type of liver cancer that cannot be removed by surgery. It is also being studied in the treatment of other types of cancer. Nexavar stops cells from dividing and may prevent the growth of new blood vessels that tumors need to grow. It is a type of kinase inhibitor and a type of antiangiogenesis agent.</n0:def-definition><n0:def-source>NCI-GLOSS</n0:def-source></n0:ComplexDefinition>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>4-(4-(3-(4-Chloro-3-trifluoromethylphenyl)ureido)phenoxy)pyridine-2-carboxyllic Acid Methyamide-4-methylbenzenesulfonate Tosylate</n0:term-name><n0:term-group>SN</n0:term-group><n0:term-source>NCI</n0:term-source></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>sorafenib</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000390251</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P319> "5T62Q3B36J"^^<http://www.w3.org/2001/XMLSchema#string> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P302> "Major Depressive Disorder"^^<http://www.w3.org/2001/XMLSchema#string> . _:vb648221 <http://www.w3.org/2002/07/owl#someValuesFrom> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C26044> . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>SORAFENIB TOSYLATE</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>FDA</n0:term-source><n0:source-code>5T62Q3B36J</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#P90> "<n0:ComplexTerm xmlns:n0=\"http://ncicb.nci.nih.gov/xml/owl/EVS/ComplexProperties.xsd#\"><n0:term-name>sorafenib tosylate</n0:term-name><n0:term-group>PT</n0:term-group><n0:term-source>NCI-GLOSS</n0:term-source><n0:source-code>CDR0000509041</n0:source-code></n0:ComplexTerm>" . <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C2194> <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#code> "C2194"^^<http://www.w3.org/2001/XMLSchema#string> .