"Prolactin 16-kD Fragment"^^ . . "Prolactin 16-kD Fragment"^^ . "Amino Acid, Peptide, or Protein"^^ . . "Pharmacologic Substance"^^ . "Prolactin 16-kD FragmentPTNCI" . "Prolactin_16-kD_Fragment"^^ . "C2047"^^ . "16K PRLABNCI" . "C1514483"^^ . "A 16 kD N-terminal fragment of prolactin formed endogenously by cleavage of intact prolactin. Possessing anti-angiogenic properties, prolactin 16-kD fragment inhibits the pro-angiogenic effects of basal fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on endothelial cell proliferation, migration, and capillary organization. This agent also induces caspase-mediated endothelial cell apoptosis and upregulates the expression of plasminogen activator inhibitor-1 (PAI-1); PAI-1 inhibits the activity of urokinase, an enzyme essential to angiogenesis. (NCI04)NCI" .